Women are born with all their oocytes, which need to stay viable for decades to ensure fertility. How are they maintained for that long? Our latest research in Nature Cell Biology reveals that oocyte maintenance involves exceptional protein longevity. nature.com/articles/s4155… (1/9)

FISHnet is a graph theory method that capture hierarchical chromatin domains using 4 key steps. (2/8)

This has been a team effort across the Cremins lab! Special shoutout to Kenneth Hoàng Phạm 🏳️‍🌈 for helping in crafting and iterating FISHnet, and Harshini Chandrashekar for helping with genomic analyses. (7/8)

I would also like to especially thank Jenn Jenn Cremins for all the thoughtful discussions and insights to help FISHnet come to life. We welcome all feedback/ discussion. We are excited to see all of the cool things waiting to be discovered! (8/8)

Next up is MASTR-seq - a protocol for Cas9-based capture of target loci for multi-modal inquiry of short tandem repeat tracts and DNA methylation at single-allele resolution using Nanopore long read sequencing. Led by chuanbin

check out Rohan's FISHnet for sequential Oligopaint data, so lucky to have been a part of Rohan's project

Finally, I'd like to give thanks to Zoltan Simandi, Harshini Chandrashekar, and Dominik Paquet for their critical wet and dry lab contributions and Jenn Cremins for guiding me through the scientific discovery and writing process. Without them, none of this would've been possible! (5/5)

K Titus with colleagues Harshini Chandrashekar Zoltan Simandi found a link among de novo enhancer-promoter loops, RNApol2 elongation, and robust gene expression upregulation during human neural lineage commitment. Collab Dominik Paquet Now published: doi.org/10.1016/j.xgen…

Excited to see this out in print! 🎉🧬

I am thrilled to share that I've successfully defended my Ph.D. from Jenn Cremins Penn Bioengineering Penn Engineering ! The big day was made more special with my family and friends present to support me! 💫

First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? biorxiv.org/content/10.110… (1)

Excited and honored to be a finalist for the Genome Organisation Australia #YoungTADAward! 🎉 Thank you for the opportunity and looking forward to sharing our work from Jenn Cremins Penn Engineering Penn Bioengineering ! 🧬✨

Congratulations Harshini Chandrashekar 💐 Using human neurons homozygously-engineered with familial AD mutations, she found a role for miswired promoter-enhancer multi-loops in dysregulated excitatory and inhibitory gene expression programs BioRxiv: doi.org/10.1101/2024.0…

Congratulations to Rohan Patel Rohan Patel: Awarded an NIH fellowship for his work to computationally explore chromatin patterns and mechanisms of loop extrusion in sequential oligopaints imaging data. doi.org/10.1101/2024.0…

Rory McIlory entered the final round of this year's Masters tournament in a position to win. After 11 years of trying, it would mean a career grand slam, placing him on the Mount Rushmore of Golf's all-time greats. He was looking good—until hole 13, when he made a terrible