Another deep learning breakthrough: Deep TDA, a new algorithm using self-supervised learning, overcomes the limitations of traditional dimensionality reduction algorithms. t-SNE and UMAP have long been the favorites. Deep TDA might change that forever. Here are the details:

AI based laser based pesticide and herbicide. No chemicals. Meet Ironman…

o filme Oppenheimer produz a sensação mais intensa de tristeza profunda misturada com alegria. A alegria dos gênios da ciência entendendo e controlando a natureza do átomo e a tristeza profunda do produto gerado.

Cell division is not always symmetric - in this review we discuss the role of asymmetric mitosis in generating phenotypic heterogeneity in cancer - journals.biologists.com/jcs/article/13…

Otto Warburg's grant application from 1921 is just one sentence – “I require 10,000 marks” – and it was fully funded.

How did we lose our tail? A simple question.. but it wasn't really asked before! We discovered a plausible scenario for the genetic mechanism that led to tail loss. Amazing that such a big change may have been caused by such a small genetic event. nature.com/articles/s4158… Bo Xia

In their Review, Julieti Buss, Karine Begnini and guido lenz LabSinal UFRGS discuss the contribution of asymmetric cell division to phenotypic heterogeneity in cancer. journals.biologists.com/jcs/article/13… #JCSCellandTissuePolarity

In this review I propose the concept of hetness, which is the capacity of generating heterogeneity during development but also in tumorigenesis. Check it out - authors.elsevier.com/a/1j3xe3IQ%7Eq…

Very pleased to share our latest preprint on MAPK dynamics and cell fate decisions in lung cancer biorxiv.org/content/10.110… . Does EGFR mutation mean MAPK is always on? NO, it shows dramatic pulses👇1/4

Published today! We found that cancer cells adapting to drug treatments don't simply switch from a sensitive to resistant state; instead there's a ‘resistance continuum’ of resistant phenotypes with epigenetically reprogrammed states. 🧵⬇️ nature.com/articles/s4158… @Gustavo_SFranca

Excelent work! I tried Ultrack in a few time lapses and it worked really well without much adjusting. Also, the segmentation workflow is amazing. I have been using it not only for videos

Thanks to guido lenz for visiting us Wellcome Sanger Institute this week.

The new world of AI taken over the Nobel

Nobel Prize in Physiology or Medicine: Biology Nobel Prize in Chemistry: Biology Nobel Prize in Physics: Sounds like Biology #NobelPrize

🚨 Great alternatives to BioRender are now available!! 📢 NIAID News offers a collection of public figures and icons for everyone to use. Check it out at bioart.niaid.nih.gov

These findings are from a systematic review in Ageing Research Reviews which examined the dose-response relationship between overall and specific types of exercise with cognitive function in older adults. sciencedirect.com/science/articl… 2/10

And it’s the cover!!

🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper link and annotated walkthrough in the thread below (1/11)

🧵 If you still think of cancer as a list of mutations, you’re missing the bigger picture. In Cell, Douglas Hanahan redefines the Hallmarks of Cancer. This is not an update, it’s a new way of thinking about cancer. Here are the 7 most relevant changes 👇 OncoAlert

More evidence that #immunotherapy works better in the morning. In a prospective, randomized phase III trial, giving first-line chemo-immunotherapy earlier in the day (<15:00) nearly doubled PFS (11.3 vs 5.7 mo, HR 0.40) and improved OS (28.0 vs 16.8 mo; HR 0.42) in advanced