Our article on preconception/preimplantation screening human embryos for pathogenic variants & mutations with #WGS go.nature.com/3cqCsi2 #genome #genetics

However, significant problems remain - these are long stretches of unknowns. journals.plos.org/plosone/articl…

Our new variant technical briefing contains updated analysis on Omicron hospitalisation risk and vaccine efficacy against symptomatic disease and hospitalisation: gov.uk/government/new…

💡May be of interest for non-Dutch: a short explainer on the 3 sources of mortality data in the Netherlands🇳🇱. 1⃣ Total and excess mortality 2⃣ Reported deaths of C19 patients 3⃣ C19-deaths based on death certificates (filled in by MD) CBS.nl Statistics Netherlands GGD GHOR Nederland RIVM /Start 🧵

3⃣ Statistics Netherlands published Cause of Death statistics, based on info of medical doctors. CBS publishes figures on this since 1899. The C19 outbreak presented CBS with a challenge that had not arisen since the Spanish flu. Explainer: cbs.nl/en-gb/corporat…

3 types of mortality data per week in 1 graph: 1⃣ Excess mortality (EM, wk50) 2⃣ Reported deaths of C19 patients (wk 50) 3⃣ C19-deaths based on death certificates (wk35) Untill now 3⃣ as high or much higher than 1⃣ or2⃣. Recently, 1⃣ is really much higher than 2⃣.

Cumulative numbers diff age groups: 1⃣ Excess mortality (wk 50) 3⃣ C19-deaths, death certificates (wk35) Since start vaccination campagne, in which 80+ and care home pop. got vaccinated first, 1⃣ did not increase for long time. Among 65-80 yes, but 1⃣ = 3⃣ during that period.

Bioinformatics (me paraphrasing: tools and methods) are 31-fold over-represented among the highest impact scientific papers of the past two decades academic.oup.com/bioinformatics…

バインコルフストア1931atロッテルダムbyウィレムマリヌスデュドック

Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis is now online Cell Metabolism Great collaboration w/Shogo Sato KenDyar Jonas Thue Treebak @lutter_dominik Paolo Sassone-Corsi Laboratory SRP DIABETES NNF Center for Basic Metabolic Research (CBMR) authors.elsevier.com/sd/article/S15…

No less than four months since CLIMB-BIG-DATA's CLIMB-COVID pipelines reached the staggering and sombre milestone of 1 million genomes, we've done it all over again and the count now stands at over 2 million UK SARS-CoV-2 genomes🧵Thread on how our system works x.com/samstudio8/sta…

Hier schieten je toch de tranen van in de ogen! #opendecultuur

Wuhan-Hu-1. Alpha, Beta, Delta Omicron/BA.1, BA.2, BA.4, XE, XD, XF. Once again, biologists do a bang-up job when it comes to nomenclature

Mutational signatures extracted from more than 12000 tumor whole genomes from #100kGenomesProject, including common and rare signatures. Great work by Serena Nik-Zainal team! science.org/doi/10.1126/sc…

Evolution is tree-like, but not a tree. This is why in pggb we make genome graphs without a guide tree. Looking for further support of this, including study targets (clades and species), to convince ever-skeptical grant reviewers of the importance of this aeon.co/essays/why-evo…

Keith Robison bombabot Ultima Genomics Flow order can be leveraged for basecalling, mapping, and variant calling. Ion Torrent did this extensively.

At Oxford Nanopore’s pathogen event - Dr. Laura Boykin Okalebo urges the global #publichealth community to stop doing “labs in a suitcase” and colonial science, but instead focus on building local in country infrastructure and jobs. #ASMicrobe

🔥3 free data science books, the most popular among our subscribers! 1. Fundamentals of Data Visualization by @ClausWilke 2. Python Data Science Handbook by Jake VanderPlas 3. Hands-On Data Visualization by HandsOnDataViz Links⬇️

rudyrucker.com/mirrorshades

I asked ChatGPT to write a FASTA parser. It returned a fully working Python implementation with comments and everything. I asked it to port it to Rust. It did that, and produced a correct Rust program that compiles without any warnings. What is this sorcery??!