Microbiota-derived vitamin B12 reduces cholinergic signalling in the nervous system - see Wookyu's paper out at Nature Cell Biology today. nature.com/articles/s4155…

A nice summary and comments on our acylspermidine story ‘The buck stops with spermidine | Nature Chemical Biology’ nature.com/articles/s4158…

Protein function is coupled to distinct branches of fatty acid metabolism - see Bingsen's PNAS paper "Amino acid- and protein-specificity of protein fatty acylation in C. elegans" just published at pnas.org/doi/10.1073/pn…

Microbiota regulate conserved lipid metabolism via nuclear receptor signaling: see Bennett's paper "Evolutionarily related host and microbial pathways regulate fat desaturation in C. elegans" just published at Nature Commun.: nature.com/articles/s4146…

Cross-phylum detection of small-molecule signatures: Ping Hsueh's lab reports the identification of a fungal GPCR sensing nematode pheromones (ascarosides), see Nature Mircrobiology: nature.com/articles/s4156…

Holoclara announced their Series A! Founded by Andrea Choe, Paul Sternberg, and Frank Schroeder, Holoclara.com is a great success story, nicely summarized here: businesswire.com/news/home/2024…

Must listen of the week: The Ascaroside Signaling PODCAST! Everything you always wanted to know about ascaroside signaling, dauer, MOGLs, and modular assembly: soundcloud.com/frank-schroede… More entertaining than "This American Life", but generated with NotebookLM!

Next up: our PODCAST on how host-microbe interactions regulate fat metabolism in C. elegans: soundcloud.com/frank-schroede…… discussing our recent paper in Nature Communications: nature.com/articles/s4146…

Bingsen's perspective on how metabolic state feeds back on protein function and physiology: "Mechanisms of metabolism-coupled protein modifications" at Nature Chemical Biology: nature.com/articles/s4158…

C. elegans as a model for how host-microbe interactions rewire conserved amino acid metabolism: Yong-Uk's paper from Marian Walhout's lab: nature.com/articles/s4225…

Congratulations to Tae, Arif, and Chris on publication of their Nature paper, reporting a new class of bile acids that regulate cholesterol metabolism: nature.com/articles/s4158…

Our start-up Ascribe Bio ascribebio.com announces investment by ICIG Ventures: agribusinessglobal.com/biopesticides/…

Marian and Safak's metabolic flux paper at Nature: nature.com/articles/s4158… Highlights include establishing the primary use of amino acids and bacterial RNA (!) as a tricarboxylic acid cycle carbon source.

Ascaroside-based start-up Ascribe featured at Forbes: forbes.com/sites/daphneew…

Bile acids as androgen receptor antagonists: amazing work by our Weill collaborators, CJ Guo and David Artis: sciencedirect.com/science/articl…

Congratulations to Dillon and Josh! Their JACS paper reporting new insights into bacterial isoprenoid biosynthesis using a masked DMAPP probe: pubs.acs.org/doi/full/10.10…