Out Now! Single-cell image-based screens identify host regulators of Ebola virus infection dynamics bit.ly/46nKLtH #EbolaResearch #Microbiology #CRISPR

Post 29 — Adaptation Underway: H5N1 Is Narrowing the Gap Toward Human-to-Human Transmission The H5N1 clade 2.3.4.4b has changed a lot since it circulated only among birds. Since 2010, it has accumulated adapative mutations that increase its ability to infect mammals, 1/10

A novel nanoparticle vaccine, based on S1-CTD, elicits robust protective immune responses against porcine deltacoronavirus | Journal of Virology journals.asm.org/doi/10.1128/jv…

⚠️Measles update US 🇺🇸 1454 cases, 42 jurisdictions, 65% kids, 96% not fully vaccinated, 12% required hospitalisation, 3 kids dead. The US Measles outbreak continues to moderate, although still breaks all records since eradication 2 decades ago.

VelociRAPTR, a platform combining yeast display with virus-like particles, maps T cell receptor interactions with antigens at high throughput. Insights could aid T cell therapy design and immune recognition models. biorxiv.org/content/10.110… #TCR #HighThroughput #VLP #Pseudotype

New study: HPV vaccines assessed with pseudotyped virus neutralisation assays 💉 Bivalent gave strong HPV16/18 responses, nonavalent gave broader protection (esp. in older groups). 🔗 frontiersin.org/journals/publi… #HPV #Vaccine #Virology #Pseudovirus #PseudotypedVirus

Viral AlphaFold Database dropped! NCBI RefSeq → 647,000 viral protein seqs MMseqs2 → ~117,000 clusters AlphaFold2 → 26,962 monomers AlphaFold-Multimer → 26,754 homodimers Foldseek → 12,894 structural clusters Enjoy.

🔥Vaccine news🔥 A study of 2,300 women has shown that HPV infections dropped by 98% (!!) in vaccinated women HPV causes cervical cancer This vaccine prevents cancer! jamanetwork.com/journals/jamap…