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Hydrazides Part II: Happy to share our latest preprint, which introduces the ethylhydrazide DS-103. DS-103 completely reverses cisplatin resistance. This work also includes the first alkylhydrazide:HDAC co-crystal structure ChristiansonLaboratory. Daniel Stopper go.shr.lc/3N9Xt4s

Happy that my postdoc Linda could contribute the dual HDAC/BET inhibitor to this very interesting study from the Kassack lab on triple combinations against bladder cancer Heinrich-Heine-Universität Düsseldorf mdpi.com/2982078

PhD student: "please don't be excited yet, these are just preliminary results, I still need to repeat the experiment multiple times" PI:

#ChemMedChem #OnTheCover A NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Receptors CCR6, CXCR1 (Matthias Schiedel and co-workers) onlinelibrary.wiley.com/doi/10.1002/cm… Finn K. Hansen Matthias Schiedel onlinelibrary.wiley.com/doi/10.1002/cm…

Let´s get the E3 ligase hopping party started with our first stop: FEM1B! Huge congrats to Felix for leading this project from start to finish, and shoutout to Irina, Martina, Heiko, Svenja, and Maria for their amazing contributions! 💪👏 Felix Feller - go.shr.lc/3Ykeyh2

Very interesting paper written by two young superstars!

I stood in line for 3 hours to vote today! 🇺🇸 It’s a small price to pay for democracy and our right to have a voice. Voting is more than a duty; it’s a privilege. Let’s participate, make our voices heard, and respect the outcome, whatever it may be.

Happy to announce that our paper on the multicomponent synthesis of quisinostat analogs as anticancer and antiplasmodial #HDAC inhibitors has been published. Congratulations to first author Daniel Daniel Stopper and all co-workers and collaborators involved! sciencedirect.com/science/articl…

Check out our latest preprint on #PHOTACs: Light-activatable PHOTACs enable the optical control of targeted HDAC6 degradation. Huge congrats to Silas Silas Wurnig , Maria, Shiyang Shiyang Zhai , and our amazing collaborators in the Nowak lab Radek Nowak ! go.shr.lc/3ZudhVq

Let´s continue our E3 ligase hopping party! Second stop: DCAF11. The switch from a CRBN to a DCAF11 recruiter converts a selective HDAC6 PROTAC into a pan-degrader. Congrats to first author Felix Felix Feller and my coworkers Heiko, Martina, Irina & Maria! go.shr.lc/3C1jgcA

The application period for the second cohort of our RTG 2873 GRK2873 is open! We are now recruiting 12 PhD students. For more information see our homepage: grk2873.uni-bonn.de/en. My own project will focus on the development of HDAC #PROTACs. Please RT! grk2873.uni-bonn.de/en/training-pr…

Kicking of the new year with our first publication: Our paper dealing with FEM1B-recruiting HDAC #PROTACs is online in #JMedChem ACS Publications Bio & Med Chem Content. We noticed selective HDAC1-3 degradation. Congrats to Felix Felix Feller, Irina, Martina, Heiko, Svenja and Maria! pubs.acs.org/doi/10.1021/ac…

New #PROTAC preprint: In this work, we utilized a non-selective ethyl hydrazide warhead for the selective HDAC6 degradation. Congratulations to co-first authors Daniel Daniel Stopper & Irina as well as Felix Felix Feller ! go.shr.lc/4jinjC0

Excited to share our latest publication on #HDAC inhibitor-based multineurotarget drugs as a potential treatment option for Alzheimer´s disease, now online in ACS Pharmacology & TS! 🎉 Huge congrats to our amazing team and collaborators! pubs.acs.org/doi/full/10.10…

Happy to share our latest paper in #JMedChem on improved antagonists targeting the intracellular allosteric binding site of CCR7! Huge thanks and congratulations to the whole team for the incredible teamwork! pubs.acs.org/doi/10.1021/ac…

Thrilled to share our #JMedChem paper dealing with DS-103! The ethylhydrazide DS-103 fully reverses cisplatin resistance and binds to HDAC6 in a manner similar to a hydroxamate. Huge congrats to first authors Daniel Daniel Stopper & Lukas and the entire team! pubs.acs.org/doi/10.1021/ac…

The next chapter of our HDAC #PROTAC story: CRBN-recruiting PROTACs based on a non-selective ethylhydrazide #HDAC warhead induce selective HDAC6 degradation. Congrats to my PhD students Daniel Daniel Stopper & Irina (co-first authors), and Felix Felix Feller. pubs.acs.org/doi/full/10.10…

Happy to share the final version of our DCAF11-recruiting #HDAC #PROTAC paper. Congrats to my co-workers Felix Felix Feller, Heiko, Martina, Irina and Maria! …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cm…

#ChemMedChem Replacing a Cereblon Ligand by a DDB1 and CUL4 Associated Factor 11 (DCAF11) Recruiter Converts a Selective Histone Deacetylase 6 PROTAC into a Pan-Degrader (Finn K. Hansen and co-workers) #openaccess 🔓 onlinelibrary.wiley.com/doi/10.1002/cm…

Thrilled to see Our FerroTac story is now out at J. Am. Chem. Soc. - Huge congrats 🙌🏻 🥳 Alessandra Salerno 👩‍🔬 Lianne and Claudia! Centre for Targeted Protein Degradation