#Fibroids are monoclonal tumors and approximately 40 to 50% show karyotypically detectable chromosomal abnormalities.

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When multiple #fibroids are present they frequently have unrelated genetic defects.

Specific mutations of the MED12 protein have been noted in 70 percent of #fibroids.

#Fibroids growth is strongly dependent on estrogen and progesterone.

Hypertension is significantly correlated with #fibroids.

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First degree relatives have a 2.5-fold risk of fibroids development, and nearly 6-fold risk when considering early onset cases.

Gynecologic ultrasonography (ultrasound) has evolved as the standard tool to evaluate the uterus for #fibroids.

A bimanual examination typically can identify the presence of larger #fibroids.

Also magnetic resonance imaging (MRI) can be used to define the depiction of the size and location of the fibroids within the uterus.

Lesions that look like #fibroids in screening, in some rare cases might be a malignant uterine leiomyosarcoma.

Compression of the ureter due to #fibroids may lead to hydronephrosis.

#Fibroids may present alongside endometriosis, which itself may cause infertility.

#Adenomyosis may be mistaken for or coexist with #fibroids.

After menopause #fibroids shrink and it is unusual for fibroids to cause problems.

Uterine artery embolization (UAE): is a noninvasive, endovascular procedure effectively treating symptomatic #fibroids.

#Myomectomy is a surgery to remove one or more #fibroids. It is usually recommended when more conservative treatment options fail.

#Hysterectomy was the classical method of #treatingfibroids. It is now recommended only as the last option.

Endometrial ablation can be used if the fibroids are only within the uterus and not intramural and relatively small.