Preprint on "Improving spliced alignment by modeling splice sites with deep learning". It describes minisplice for modeling splice signals. Minimap2 and miniprot now optionally use the predicted scores to improve spliced alignment. arxiv.org/abs/2506.12986

🚀 Xaira Therapeutics has just dropped a game-changer for AI-driven biology. Today, we unveiled X-Atlas/Orion, the largest publicly available genome-wide Perturb-seq dataset to date—spanning 8.4 million single cells with perturbations across all ~20,000 human protein-coding

A new paper in Nature Ecol & Evol by Rosa Fernández et al. shows a #punctuated burst of genome evolution in #annelids as they transitioned from marine to land and freshwater habitats.

Is it just me finding 10x data difficult to understand what product authors were referring? some annotated their library as "HTO" but never worked with CR multi (multiplexed but treated as FB instead of CellPlex)

New online! The evolutionary foundations of transcriptional regulation in animals bit.ly/4lHk7QL

Glad to hear tons of feedback from #Gmeeting2025 Fantastic meeting to learn heterogeneity of granulocytes and the studies of them ☺️

I had a dream of studying animals when I heard Dr. Jane Goodall’s legacy in my early childhood Back then I never thought I would finish my dissertation in studying animals genomes I thank her so much for her inspirations on that little kid 🥹

『#はたらく細胞』原作・清水茜（清水茜|イエローフレイム）先生より、坂口志文先生のノーベル生理学・医学賞受賞のお祝いイラストをいただきました。坂口先生、本当におめでとうございます！

OMG I never seen this in my whole life… Ohtani is surely giving up being human 😂😂

Benchmarking large-scale single-cell RNA-seq analysis biorxiv.org/content/10.110…

Among full pipelines, rapids singlecell was the fastest, whereas OSCA and scrapper achieved the highest clustering accuracy in datasets with known cell identities. Performance differences were largely driven by the choice of highly variable genes (HVGs) and PCA implementation.

My biggest improvement this year was understanding how and when to talk with AI In bioinfo field it’s always about learning new tools urself and AI brings u on a rocket Oh my google+stackoverflow days PhD training needs a reboot in an AI world nature.com/articles/d4158…

I am super impressed by 5.1 now Just threw a vague problem to it cuz I don't want to check line by line myself Did not realize actually there were a lot missing info and I did not explain first It figured out all missing context itself and got me the correct answer Thats a wow