Publishing nowadays vs publishing in the 90s

Today’s achievement: finally got my CMA-targeting reporter to work! 🎉🎉🎉Lots of CMA in these cells #CMA #parkinson’s #SaturdayVibes

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism nature.com/articles/s4146…

Very excited to share a work I have contributed to during my Master Thesis in the Klann Lab at NYU. This work led by Dr. Francesco Longo unveils how cell type-specific disruption of cortico-striatal circuitry causes repetitive behavior in FXS mice.

Celebrating Christmas far from home for the second time in a row has made me capable of things I’ve never even imagined . Like helping out Luca Finetti making 889g of tortellini from scratch. Well, I didn’t really have a choice, did I ? Luca Finetti 😂

Congratulations to the Krembil 2022 Fall Postdoctoral & Clinical Fellowship Competition winners! Federica Albanese (supervisor Dr. Lorraine Kalia kalialabs) Nouri Shahrzad (supervisor Dr. Sowmya Viswanathan) and Maximilian Scherer (supervisor Dr. Luka Milosevic Luka Milosevic). 👏

Beyond excited to finally share my new first author paper, published on PLOS One, about octopamine and tyramine signaling in Aedes aegypti! Thanks Jean-Paul Paluzzi for the productive collaboration! #mosquitoes 🦟 journals.plos.org/plosone/articl…

The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy cell.com/cell-reports/f…

#WednesdayWisdom comes from Dr. Luca Finetti, #PDF, Lange& Orchard Lab, as his paper Octopamine and tyramine signalling in Aedes aegypti: Molecular characterization and insight into potential physiological roles was published by PLOS One zurl.co/Gxjm Luca Finetti

Federica Albanese I found the perfect wedding favor for our science-theme wedding! A mini cute #westernblot membrane! However, without antibodies, they are expensive 👆🏻

As a guest editor for JoVE I’m happy to share the method collection on the role of the biogenic amines in invertebrate #physiology and #behavior! 🦟🐜🐝🦗 Learn more and contribute now: app.jove.com/methods-collec… #drosophila #celegans #mosquitoes

Looking for CMA-active #lysosomes co-stained with LAMP1 and LAMP2A. I do love airyscan super-res… ❤️

#SBAM! What if the vitellogenin release from fat body needs a tyramine-mediated signal? I investigated this in my last first author paper published in Insect Biochem Molec Biol! Thanks Federica Albanese for your amazing help! doi.org/10.1016/j.ibmb… Elsevier | ScienceDirect Elsevier

In collaboration with Philip Kim's lab and colleagues, kalialabs identified a targetable protein-protein interaction within the ESCRT-III pathway that reduces alpha-synuclein toxicity in preclinical models of #Parkinson's Nature Communications rdcu.be/dae2W

Beyond excited to share this amazing work from kalialabs in which I contributed published on Nature Communications on mitigation of neurodegeneration in PD preclinical models by disrupting the interaction between alpha-syn and CHMP2B.

Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes dlvr.it/SnPb92

New paper from Dimitri Krainc & Northwestern Feinberg School of Medicine colleagues reports neurons carrying PARKIN variants exhibit decreased mitochondria-lysosome contacts via destabilization of Rab7; This = amino acid accumulation in lysosomes & their deficiency in mitochondria science.org/doi/10.1126/sc…

Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro | incredible ⁦beth stevens⁩ nature.com/articles/s4159…

Really excited to see this paper out on Cell Reports ! 🎉🎉 Congrats to Francesco Longo for the amazing work! Very happy to have contributed to it!