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No single US news source is consumed by more than 25% of Americans, whereas 60% of Brits regularly watch/read/listen to the BBC. That makes it very hard for partisan echo chambers to form. (searchable interactive chart here public.flourish.studio/visualisation/…)

Funny to see the PCA vs UMAP debate start to take on a culture war angle. In reality, the latter simply doesn't identify basic population structure correctly. Here's an example with three-way admixture: admixed individuals get mapped almost arbitrarily.

1/ In Ausgabe 6 von #EsoGulasch schauen wir uns Rudolf Steiner an. Steiner ist Begründer der Anthroposophie und wird in esoterischen Kreise bis heute als Philosoph und Wissenschaftler verehrt. In Wahrheit war er grössenwahnsinniger Okkultist, Antisemit und Rassist. 🧵

Does anyone know if the TOPMed imputation panel SNPs and their frequencies are publicly available somewhere?

I’m very happy to share that our work on the genetic overlap between schizophrenia and height is now available on medRxiv 🎉 Link: medrxiv.org/content/10.110… quick summary below (1/9)

So excited to finally share our X chromosome wide association study (XWAS) of Alzheimer's disease (AD)! Simultaneously the largest genetic association study of AD to date (N=1,152,284). Find out more about the top prioritized gene, SLC9A7 (aka NHE7), here: medrxiv.org/content/10.110…

It pains me to see facile critiques of GWAS on here from our clinical/biostats friends while the many actually good reasons to be critical of GWAS get little attention. So here's a thread on what GWAS does, what critics get wrong, and where GWAS is genuinely still lacking. 🧵:

New pre-print from the PGC Consortium #Depression Group: Multi-ancestry GWAS of depression with 685,000 cases identifies 697 independent associations, implicating known & novel drug targets. 🔗 medrxiv.org/content/10.110… 1/n

Congratulations to BRAINSCAPES PI Danielle and Marijn Schipper for their co-publication in Nature! They collaborated with Camiel Mannens and Sten Linnarsson who created a chromatin accessibility map during early embrionic human neurodevelopment. See: nature.com/articles/s4158…

38 years ago a woman in Coventry sent a letter to some scientists. That letter went on to be the most important in Alzheimer's research. Last year, I met Carol Jennings, who wrote it. 1/ thetimes.co.uk/article/e78c47…

I was reading the recent nature paper on the impact of human genetics on drug success (nature.com/articles/s4158…). I found one of the findings particularly interesting. ​ This is a follow-up work of Matt Nelson's famous 2015 paper published in Nature Genetics

*Ten* 3-year post-doc/assistant prof jobs advertised for our Pioneer Centre for SMARTbiomed - address key questions in common complex diseases through development of new stat/comp tools & software. A new Denmark-Oxford collaboration. Critical mass! smartbiomed.dk/join-the-centr…

I will never skip over the acknowledgments again science.anu.edu.au/news-events/ne…

Am I the only one constantly receiving invitations to review a Mendelian Randomization paper? They make up about 90% of all review invitations I receive

"Although [whole genome sequencing] results in an approximately fivefold increase in the total number of assayed variants over [exomes + imputation], the number of detected signals differed by only 1% ..." nature.com/articles/s4158…

Hello! We recently shared a preprint where we aggregated rare variants in the UK Biobank (N~40k) to find genes associated with variation in brain volume doi.org/10.1101/2024.0…. There are more details in the thread below. If you have any feedback, please send me an email. (1/13)

Today, the Guardian, alongside HOPE not hate , today publish an in depth undercover investigation into the efforts of a network of far right race and IQ obsessives, who have been trying to influence discourse about race science. theguardian.com/world/2024/oct…

Last day of #wcpg2024 and #ctglab crew still looking shiny and fresh after a whole week of midnight karaoke 😎

This is not at all why we're leaving X. It's become a misinformation cesspool and it's impossible to have thoughtful arguments here any more. Have you tried engaging with any "vaccine skeptics" here? Evidence and facts have no meaning here. It's a pure propaganda engine. 1/

I lost the count of how many posts I saw about the Keto-CTA study the last days. One issue that directly relates to the lack of association between ApoB/LDL-C and plaque progression that I haven't seen anyone talk about is collider bias👇