.Oana ursu , @JamesTNeal, Jesse Boehm & colleagues unveil a massive-scale method for gaining a rich understanding of how mutations impact cell state, & question the practice of dividing cancer mutations into "drivers" & "passengers." broad.io/sc-eVIP #variant2function

This is the first chapter of a story about courageous patients and their families, of multidisciplinary teamwork, and hard-fought steps forward to effective therapy for #DIPG #DMG, a universally lethal cancer of the brain and spinal cord.🧵(1/) nature.com/articles/s4158…

Congrats to CureSearch Acceleration Initiative Award recipients Mariella Filbin Joshua Bernstock, who are working with partners UAB Brigham and Women's Hospital @AvideaTech to develop a combination immunotherapy to improve outcomes in pediatric high-grade gliomas: ms.spr.ly/6013wJ33W

From the February issue: Repurposing vandetanib plus everolimus for the treatment of ACVR1-mutant diffuse intrinsic pontine glioma by C. Jones, Carceller, @diana_mcarvalho et al. bit.ly/3BHmUDO The ICR The Royal Marsden NHS Foundation Trust #DIPG #ArtificialIntelligence

We are hiring!! Searching for a motivated wet-lab staff scientist and computational scientist to lead cutting edge #SingleCellMultiomics and #SpatialTranscriptomics in childhood brain tumors, as well as #TumorCellShapeShifting projects. Please RT and DM if interested. 🥳

Its finally out! copper induced cell death, or #cuproptosis , a new form of regulated cell death induced by copper ionophores targeting lipoylated (there is such a thing) and Fe-S cluster proteins in a process that is FDX1 dependent Broad Institute science.org/doi/10.1126/sc…

It's out! Our new paper on exploring the effects of subclonal interactions between diffuse midline glioma cells and their ability to spread using a computational and experimental framework we developed. Ketty Andrea Sottoriva The ICR Cell Reports cell.com/cell-reports/f…

Thrilled to see our joint story on VRK1 dependency in neural-lineage cancers (including DIPG) out! This was a wonderful collaboration with Bill Hahn and Kim Stegmaier, led by our three fantastic postdocs - grateful to be at Dana-Farber where cross-disease projects are possible!

Check out the Cancer Discovery papers highlighted in the latest AACR Journals collection on #PediatricCancers. bit.ly/3gL4NXA

The December issue of Cancer Discovery is now online! The newest cover to add to my office wall highlights work by Jun Qi Lab Mariella Filbin and colleagues & Zhiguo Zhang and colleagues showing H3K27M-mutant #glioma is dependent on SMARCA4 🧠aacrjournals.org/cancerdiscover…

Huge congratulations to Ilon Liu Li Jiang and Mariella Filbin !! 🥳🥂

Papers featured on the cover of CD: BAF in H3K27M-#glioma, by Eshini Panditharatna, Joana Marques, Jun Qi Lab, Mariella Filbin et al Dana-Farber and Epigenome Programing by H3.3K27M Mutation Creates a Dependence of #PediatricGlioma on #SMARCA4. bit.ly/3F7WOfg Columbia Medicine

In the Spotlight: Epigenetic rewiring underlies #SMARCA4-dependent maintenance of progenitor state in pediatric H3K27M diffuse midline #glioma, by Mary Clare Beytagh and William Weiss. bit.ly/3PdobZT UC San Francisco

Congratulations to Diana Lu, MD, PhD & the team on this really nice story! 🎉

I came to study Ewing sarcoma in memory of my friend Bryan. It has been such a privilege to study this disease and I am so honored to have this work published. nature.com/articles/s4155…

1/ Pre-print alert! Our new study led by talented Stanford Medicine student Sol Savchuk 🇺🇦 together with Michelle Monje🎗️ 🟦 illustrates that neuronal activity regulates the progression of small cell lung cancer #SCLC in the lung and brain. #CancerNeuroscience. 🧵… biorxiv.org/content/10.110…

The #Hallmarks of #Cancer constitute a theoretical framework for rationalizing the vast complexity of cancer & its underlying mechanisms. Here we discuss nervous system-cancer interactions ‘‘enabling’’ hallmark functions & consequent cancer pathogenesis sciencedirect.com/science/articl…

In recognition of Brain Cancer Awareness Month, the #CancerMoonshot is convening a forum at the White House to accelerate progress on two of the deadliest brain cancers, Glioblastoma and Diffuse Intrinsic Pontine Glioma. Tune in at 1pm tomorrow (Thursday): youtube.com/watch?v=kq8Hed…