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Just resurfacing this thread from last year on why I think current seq -> expr. models do not really work. Some nice evidence from @lal_avantika 's Kipoi seminar today on their Decima model that shows strong evidence in support of my opinions on how to solve this problem.

Our paper on using machine learning to predict the impact of rare genetic variants is out! #DeepRVAT utilizes a fully data-driven approach to analyze annotated variants. DKFZ press release: dkfz.de/en/presse/pres……Publication in Nature Genetics: nature.com/articles/s4158…

Good morning humanity

📢Our preprint on deep learning for carotid plaque detection in 170,000 UK Biobank ultrasound images is out❗️ 👉robust associations of plaque presence/count with cardiovascular events🧠🫀 👉largest GWAS for carotid plaque (29,790 cases/36,847 controls)🧬 medrxiv.org/content/10.110…

Super excited to finally post about our RNA foundation model, led by our very own Ali Saberi (not on Twitter), with Hani Goodarzi , Amin Emad , and Vishnu Ram. LoRNA-SH is splice-aware, takes as input the entire pre-mRNA, and models isoform diversity biorxiv.org/content/10.110… 1/n

Excellent analysis from the FT, as always

100GWh is a big deal

Street light helping a small patch of leaves hold on to summer.

Ok, I'll bite...🧵

The Preston plot The Guilsborough graph The Cheadle chart

Just added more 'Step Cat' handmade prints into our lovely little online art shop. Grab one quick before we run out! Ooh, they arrive ready for framing which makes them fab gifts! Shop here> littleramstudio.etsy.com #shopindie #ChristmasShopping #giftideas

Forget Oktoberfest. I celebrated Jarre-fest

Great turnout for my journal club today 👍🏼

Hunkering down for the evening in this illustration (taken from an edition of 'The Wind in the Willows') by Chris Dunn 🙂

We have a Alzheimer's Society VIDA DTC PhD studentship using the UK Biobank and physiological techniques to study the links between hypertension and dementia. A collaboration with James Eales, Prof Wardlaw and Dr Chappell from The University of Edinburgh. findaphd.com/phds/project/v…

Design for a Jacquard Woven Wall Hanging, ca. 1927 by highly influential Bauhaus textile artist Gunta Stölzl #WomensArt

🧠 Blood flow & immune response are key to understanding dementia. The Alzheimer's Society funded VIDA DTC unites 4 UK institutions to train future leaders tackling these challenges. 9 PhD's available, 14 projects to choose from. Apply by 20 Dec dementiaresearcher.nihr.ac.uk/phd-studentshi…

Tory leader Kemi Badenoch - and all the anti-net zero zealots - getting educated about the basics of energy supply live on national TV

Identification of causal genes and mechanisms by which genetic variation mediates juvenile idiopathic arthritis susceptibility using functional genomics and CRISPR-Cas9 medrxiv.org/cgi/content/sh… #medRxiv

Harry Pritchard and I are currently offering a PhD combining a data-science with a physiological approach to find therapeutic targets for dementia and hypertension. We're looking for someone interested in both physiology and data-science techniques. findaphd.com/phds/project/e…