In patients with knee osteoarthritis and overweight or obesity, metformin, 2000 mg/d, for 6 months had a moderate and statistically significant effect on knee pain reduction compared with placebo. ja.ma/43TzAae

ADA Issues New MASLD Guidelines ⁦Divya P. Kumar (She/Her)⁩ ⁦M Shafi Kuchay⁩ ⁦James Joseph⁩ ⁦Dr. Om Lakhani, MD, DNB (ENDO)⁩ ⁦Sandeep Tak MD(AIIMS Delhi), FACE⁩ ⁦SAMIT GHOSAL⁩ ⁦Dr Sandeep Rai⁩ medscape.com/viewarticle/ad…

Presented at #ERA25: In the CONFIDENCE trial in persons with chronic kidney disease and type 2 diabetes, combination therapy with finerenone and empagliflozin led to a greater reduction in the urinary albumin-to-creatinine ratio than either drug alone. Full trial results:

First biopsy-based RCT. MASH improvement in 53% of participants with dapagliflozin vs. 30% with placebo group (P=0.006). MASH resolution in 23% vs. 8%. Fibrosis improvement in 45% vs. 20% (P=0.001). SGLT2 inhibits hv huge benefits in fatty liver disease. bmj.com/content/389/bm…

New Review (Anoop Misra, S. Joshi, A. Mithal) in #Diabetes & Metab Syndr questions rebranding #Malnutrition-Related Diabetes Mellitus (MRDM) as "#Type5 Diabetes." · Declining #undernutrition · Weak #evidence, outdated #criteria · More research needed before reclassification.

Most people have heard of DNA but what about PNA? They are a synthetic peptide nucleic acids (PNAs), that bind even more strongly to nucleic acids and are not broken down in the body by enzymes that target DNA or RNA. These qualities make them good drug candidates. Two drugs are

Just a reminder that all this spectacle started with Indian's (both patients & doctors) obsession with injection for minor issues which can well be treated with oral treatment and use of inappropriate medications (by doctors, in this case vit B12 for sciatica) which is totally

Clopidogrel was associated with reduced risk of thrombotic and bleeding outcomes compared to aspirin. ja.ma/43Q3YkR

Early statin use immediately after a type 2 #diabetes diagnosis can reduce cardiovascular events by one-third. ahajournals.org/doi/10.1161/JA…

#Metformin initiation in women >60 yrs, with type 2 diabetes. increased chances of reaching exceptional longevity, 90 years and beyond, compared with sulfonylurea initiation. academic.oup.com/biomedgerontol…

Metformin: An Old Drug with New Tricks—Promising Role in Vascular Aging and Cardioprotection link.springer.com/article/10.100…

We present guidelines for #MASLD diagnosis and management in #India — developed first globally (before #ADA), fully India-focused, free of industry influence, original, unbiased, and based on our group’s key #research papers.

This breakthrough, led by researchers at the University of Edinburgh and published in Nature Chemistry (2025), demonstrates a novel way to upcycle plastic waste into valuable pharmaceuticals while reducing reliance on fossil fuels. However, commercial application requires further

Today, NEJM reports that Efruxifermin (an FGF21 agonist) is the first drug to reduce fibrosis in compensated cirrhosis due to NASH. This effect is seen after 96 weeks, so patience is key. Could combining Semaglutide make it even more powerful?

Stem Cell Therapy Zimislecel Shows Promise in Type 1 Diabetes - EMJ ⁦Banshi Saboo⁩ ⁦Dhruvi Hasnani⁩ ⁦Peter Davies⁩ ⁦Sandeep Tak MD(AIIMS Delhi), FACE⁩ ⁦Tanja Dudenbostel, MD, FASH, FAHA⁩ ⁦Jyotsana Rangeen⁩ ⁦Blue Circle Diabetes Foundation⁩ ⁦Dr. Purvi Chawla⁩ emjreviews.com/diabetes/news/…

Diabetes, Metabolic and Nutrition Clinics of India (2/3). Please read. (3/3) #Metformin and #KidneyProtection, Metformin Protects Kidney Function #Lp(a)-Lowering Agents Development: New Agents Lower Lp(a) #GLP-1 Agonists and #Cancer: GLP-1 Agonists drive.google.com/file/d/1FqRqvC…

Autoimmune Primary Adrenal Insufficiency: Understanding the Past, Present, and Future - Endocrine Practice endocrinepractice.org/article/S1530-… Dr Lakshmi Nagendra MD,DM (ENDO) Dr.Shinjan Patra DM Endocrinology Dr ABM Kamrul Hasan Dr. Deep Dutta Dr Pooja Garg Dr Nitin Kapoor Anish Kar Sandeep Tak MD(AIIMS Delhi), FACE hormone_healer mariagrazia girone Anna Bokor

🚨 Excited to share that my review article on MASLD pharmacotherapy is now published in the July 2025 issue of the Journal of the Association of Physicians of India (JAPI)! Here is a short thread 🧵 about it. japi.org/article/japi-7…

Chronic venous insufficiency #CVI or #VaricoseVeins, is when leg veins struggle to pump blood back to the heart, causing swelling, aching, or heaviness. Damaged vein valves let blood pool, like a backed-up pipe. Early on, it’s uncomfortable but manageable with lifestyle changes