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Miharu Maeda, Kota Saito et al. 秋田大学【公式】 present a novel method, the Small GTPase ActIvitY ANalyzing (SAIYAN) system, for detecting the activation of endogenous small #GTPases via fluorescent signals utilizing a split mNeonGreen system. hubs.la/Q02K0Kq30

Have you ever wondered why some cell lines are easy to edit with CRISPR-mediated gene editing, while others are more difficult? Our paper is now online and offers an interesting answer: nature.com/articles/s4158…

"Female health has been historically understudied, with grave consequences for their wellbeing and health equity." A Review in The Lancet Diabetes & Endocrinology outlines the role of sex steroids on the female brain and on the risk for diseases more prevalent in females: hubs.li/Q02KWjg_0

The 10 biggest medical research papers from this week (🧵) 1. A brain implant in a man with motor neuron disease (ALS), who could no longer speak, decoded his neural activity and allowed him to speak via a computer - in his own voice (Study: nejm.org/doi/full/10.10…)

Excited to announce…..it’s finally arrived (!!) nature.com/articles/s4155… A big thank-you to my team (particularly Robert Ju), co authors & #FutureFellowship funding from Australian Research Council Importantly- a big shoutout to Daryl JV David Nature Cell Biology for their support. 👇tweetorial 👇

New paper collaboration with the Cullen lab. @PeterJCullen1 led by Rebeka Butkovič, Alex Walker and Michael Healy. Here we identify the mechanism by which SNX17 mediates cargo recruitment to the Commander complex for endosomal trafficking. nature.com/articles/s4146…

Ivaska Lab latest exciting findings in collaboration with Wickstrom-Lab Kate Miroshnikova Scita_Lab Karolina Punovuori driven by Jasmin Kaivola - Restoring mechanophenotype reverts malignant properties of ECM-enriched vocal fold cancer biorxiv.org/content/10.110…

1) Excited to share a ms entitled: Integrin-activating Yersinia protein Invasin sustains long-term expansion of primary epithelial cells as 2D #organoid sheets. It describes an alternative to #Matrigel biorxiv.org/cgi/content/sh… A thread:

From stress fiber to focal adhesion: a role of actin crosslinkers in force transmission frontiersin.org/journals/cell-…

What happens when unexpected happens!? 1) Johanna Lilja Ivaska Lab #JasminKaivola identified SHANK3 as a KRAS inhibitor 2) predicted SHANK3 depletion boosts KRASmut tumors 3) observed SHANK3 depletion kills KRAS-cells by ERK hyperactivation, apoptosis rdcu.be/dTQDP

Live-cell imaging and CLEM reveal the existence of ACTN4-dependent ruffle-edge lamellipodia acting as a novel mode of cell migration sciencedirect.com/science/articl…

Relationship between chromosomes (orange) and the mitotic spindle (green) in four stages of cell division, as seen by Bessel Beam plane structured illumination microscopy cell.com/fulltext/S0092…

Collagen VI deposition primes the glioblastoma microenvironment for invasion through mechanostimulation of β-catenin signaling academic.oup.com/pnasnexus/arti…

Ivaska Lab THE review on 'everything' you have ever wanted to know about integrins in cancer, invasion and migration. Many cool new concepts highlighted from the beautiful research from experts in the field 👇@MeganChastney #VMLeppänen #JasminKaivola rdcu.be/dVB6n

New pre-print! Gautier FOLLAIN and team develop a super cool pipeline to work out the intricacies of immune and PDAC cell adhesion to HUVECs and extravasation under flow. Fantastic collab with @guijacquemet lab and Research group of Professor Marko Salmi. Congrats🥂 Take a look here: biorxiv.org/content/10.110…

1/4 🧬 New metastasis research! TNBC and HER2+ breast cancers utilize tumor architectures and stromal interactions when colonizing the brain, with implications for targeted treatments for brain metastasis. Siting Gan MassagueLab Memorial Sloan Kettering Cancer Center cell.com/cancer-cell/ab…

Women lose >90% of their #eggs by their mid-30s, with persistent #DNADamage driving this loss. But why isn’t this damage repaired? Our new work in Current Biology, led by Ninadini Sharma, reveals the causes of high DNA damage in aged oocytes.🧬💥 bit.ly/48e35Ee (1/13)

This is great! NIAID News have launched a collection of public domain illustrations (currently 550 individual icons) bioart.niaid.nih.gov

The most recent preprint from our most recent PhD graduate Dr Nicolas Pasquier. Orientation of mucinous CRC apicobasal polarity is regulated by tumor-stroma interactions. This work was a collaboration with JaulinLab at the Gustave Roussy Institute. biorxiv.org/content/10.110…

Excited to share some of my PhD findings! Go check out how A/B polarity orientation is controlled in CRC metastasis Ivaska Lab JaulinLab ▶️ biorxiv.org/cgi/content/sh…