Studies show atopic patients do not always respond to biologics, particularly those with greater disease severity #SevereAsthma #ACAAI

Treatment options are limited for non-TH2 patients #SevereAsthma #ACAAI

There's a large unmet clinical need for treatment options for non-eosinophilic and steroid resistant severe asthma #SevereAsthma #ACAAI

Michael Foggs ...and frustrating to realize that steroids may actually make them worse, and that we lack a method to accurately ID #ACAAI

. Robert Rogers Inhibition of neutrophil apoptosis by steroids facilitates this process, a big problem! #SevereAsthma #ACAAI

Targeting ASM can supplement therapeutic approaches directed at inflammation #SevereAsthma #ACAAI

GINA has included #BronchialThermoplasty as add-on therapy in Step 5 along with anti-IgE #SevereAsthma #ACAAI

Societies, including ACAAI, also support use of BT for properly selected patients #SevereAsthma #ACAAI

Important to assess exacerbation frequency (2 or more in past 12 months) and… #SevereAsthma #ACAAI

...longitudinal lung function decline with spirometry to determine patient refractory to current treatment #SevereAsthma #ACAAI

Patient medical history, asthma co-morbidities and lung function are important #SevereAsthma #ACAAI

Induced sputum eoshinophils will be difficult to do and uncomfortable for the patient #SevereAsthma #ACAAI

Assessing if asthma is non-eosinophilic or non-atopic also important to determine if biologics…con't #SevereAsthma #ACAAI

...will not be effective and alternative options need to be considered #SevereAsthma #ACAAI

Absolutely! Systemic corticosteroid use at any dose is problematic, as are excessive oral steroid bursts #SevereAsthma #ACAAI

Risks can outweigh the benefits due to many potential systemic side effects that include…con't #SevereAsthma #ACAAI

...osteoporosis, cataracts and glaucoma, adrenal suppression, thinning of skin with easy bruising #SevereAsthma #ACAAI

Alternatives to reduce or wean off OCS and ICS should ALWAYS be considered to minimize side effects #SevereAsthma #ACAAI

BT, along w/emerging biologics, are options to consider for uncontrolled severe asthma requiring ICS & LABA #SevereAsthma #ACAAI

This also includes patients on OCS and omalizumab #SevereAsthma #ACAAI