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University of Superabundant Coaches

In a new preprint led by Nikhil Milind, we explored a fascinating paradox: For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?

1/7 🧬 New Preprint Alert: Our study highlights the risks of using divergent reference genomes in population genomics. The choice of reference genome can skew key inferences about demography, diversity, and selection. Read on for insights! biorxiv.org/content/10.110…

Our daughter's wonderful teacher and her family lost everything in the Eaton fire. If you can spare a few dollars to help out, I would be grateful gofundme.com/f/help-the-lim…

Excited to see this out! Fast, powerful methods for single cell mapping using count based models

VERY excited to announce a pre-print that represents the culmination of several years of work*: “On ARGs, pedigrees, and genetic relatedness matrices” doi.org/10.1101/2025.0… Led by Brieuc Lehmann with contributions from Hanbin Lee Luke Anderson-Trocmé Jerome Kelleher Peter Ralph

My paper about type I error rates in Qst/Fst comparisons is now published in Genetics Society of America. Check it out here: academic.oup.com/genetics/advan…

In a new #GENETICS research, Dandan Peng, Mulder, and Doc Edge evaluate the performance of several ancestral recombination graph (ARG) estimation methods used for determining the historical time course of a population-mean polygenic score. Read more: buff.ly/Xr9nFjB

In population #GENETICS, Q-ST and F-ST calculations help compare the amount of trait differentiation on one or more traits in genome-wide genetic variants. Using simulations Liu and Doc Edge, show the effect of various choices made while computing Q-ST. buff.ly/313bkfU

Hanania advocated passionately against "race mixing" for years, so he knows what he's talking about here. But it's worth adding that race-IQ obsessives also tend to make very poor predictions about the future. Let's review ...

In the right conditions, antibiotic resistance can happen extremely fast. Here is an example from my own work of bacteria overcoming an antibiotic in just eleven days in a giant petri dish: 1/

This entire line of research, after being repeatedly selected in rigorous open national competitions for funding, was cut this week as collective political retribution x.com/baym/status/19…

I went on WBUR today to talk about the grant terminations and the importance of basic medical research wbur.org/news/2025/05/1…

When should adaptation arise from a polygenic response versus few large effect changes? biorxiv.org/content/10.110… #biorxiv_evobio

Mutation-selection-drift balance models of complex diseases biorxiv.org/content/10.110… #biorxiv_genetic

latest paper from the lab led by PhD student Gilia Patterson. Gilia has developed a spatially explicit deep learning method for close kin mark recapture that we think will be extremely useful for conservation biology biorxiv.org/content/10.110…