Happy to share preprint of our exciting work on Parkin E3 ligase which is heavily mutated in Parkinson's disease. A new feedforward mechanism of Parkin activation. doi.org/10.21203/rs.3.… #ubiquitination #E3 ligases # Parkinson's #PINK1# Parkin E3 ligase IISER Bhopal Department of Biotechnology

Read this #preprint on Research Square: A new feedforward mechanism of Parkin activation researchsquare.com/article/rs-285…

Nothing else is as pleasant as staring at your high resolution density map. New data from very talented student of my lab @Diptiranjanlenka IISER Bhopal #X ray crystallography

An outstanding student of our lab receives highly prestigious PMRF fellowship@ Dipti Ranjan Lenka. Many congratulations Dipti! IISER Bhopal Dept of Biological Sciences (DBS), IISER Bhopal

We demonstrate the mechanism of substrate specificity on Parkin and solve the puzzle of Parkinson's disease mutation. New insights into Parkin activation by NEDD8. Credit goes to exceptionally talented students. biorxiv.org/content/10.110… IISER Bhopal Dept of Biological Sciences (DBS), IISER Bhopal Department of Biotechnology

Research "Intricate mechanism (s) of substrate specificity & loss of function on disease mutation (K211N) of Parkin" published in biorxiv doi.org/10.1101/2023.1… Congratulations Dipti, Shradha & Dr Atul Kumar, Asst Professor Dept of Biological Sciences IISER Bhopal Ministry of Education

Out now! New insights into the activation mechanism of #Parkin E3 ligase, an important candidate of mitophagy and Parkinson's. Dipti Ranjan lenka Shakti Dahe Odetta @pritranjansahoo Alan Prescott Miratul Muqit click here elifesciences.org/articles/96699 #iiserbhopal

Out now cell.com/structure/full…. We show mechanisms of specificity on two look-alike pockets of Parkin for its activators (pNEDD8/pUb/pUbl), and loss of Parkin activity due to Parkinson’s disease mutation K211N. Dipti Ranjan lenka IISER Bhopal Department of Biotechnology SERB Structure

Many congratulations Dipti Ranjan lenka for receiving best poster award at recently concluded @ProUPS25. IISER Bhopal Dept of Biological Sciences (DBS), IISER Bhopal

Many congratulations Gloria Grace Parmar, for successfully defending your dissertation and becoming Dr. Gloria.