In October 2024, I that "something is deeply wrong" with what we now call virtual cell models. A lot has happened since then. How am I updating? 🧵 x.com/ekernf01/statu…

TIL that the Haotian of our weekly meetings is in fact the Haotian Du (TRaCer I & II). Boston is amazing. P.S. sorry in advance for all the 1:1s you’re about to get

they did diffusion on * checks notes * a house

After a 4-year journey, we are super happy to see this paper out in Nature Communications - Katarina Elez et al: High-throughput molecular dynamics + active machinelearning enable efficient identification of an experimentally-validated broad coronavirus inhibitor. nature.com/articles/s4146…

In biology, scaling laws work... ...until they don't. For fitness prediction, protein language model performance increases with model size until it plateaus and then degrades. As training loss (NLL) goes down, models start to predict higher sequence likelihoods and correlate

ICYMI here is our Machine learning for protein engineering seminar talk on RLXF: youtube.com/watch?v=MF5JDj…

Preprint: TCR-enriched nanoscale vesicles shed by activated T cells (ectosomes) are transferred to antigen-primed B cells, where they engage and cluster cognate pMHCII, triggering signaling and specific IgG antibody production biorxiv.org/content/10.110…

6am start, 13 hours, 31 miles, SF to Foster City My legs are jello, and I’m going to be waddling for a week

Looking clean in the green. Anyone building on AR hit up Udit Karthik for some insane apps (or a brisk workout)

don’t build slot machines don’t fake humans don’t hide the messy truths don’t create black boxes don’t make people feel stupid don’t extract value or attention don’t optimize for vanity metrics don’t gatekeep knowledge don’t make tools that divide don’t sacrifice agency for

No doubt this line of research will be instrumental to precision and, dare I say, personalized oncology

dhuv.io (ie the reference is personal)

Once the models are smarter than we are, we may perceive that intelligence has plateaued even if it continues to increase.

STA really cooked with this one

Regrettably this city has grown on me far more than I had anticipated.

🐐 x 🐐. Only in Beantown Martin Pacesa Sergey Ovchinnikov

Incredible vibe in the room and super stimulating discussions! I am so honored to have been invited to talk at the BPDMC ❤️

the world of AI is crazy right now because an intern will be like "sorry, let me double-check the numbers on that tonight" and then spin up an experiment with the power of 10,000 washing machines

So it’s real! 3 weeks ago I set a reminder that if in 3 weeks a someone didn’t come out refuting their claims then it was real and all of the frontier labs were quietly working on replicating it and integrating it. Brilliant thread on HRMs breaks down what worked and didn’t

For punctuation nerds only! Hyphens are used for compound modifiers. Otherwise, no hyphen. Example: "T cells have T-cell receptors."