Our latest data proposes that Lynch-associated CRCs have similar immune profiles across all MMR gene defects, challenging the idea of gene-specific immunological differences. #LynchSyndrome #CancerResearch Maartje Nielsen medrxiv.org/content/10.110…

A workflow integrating imaging mass cytometry and mass spectrometry-based imaging on the same tissue sample, developed by de Miranda Lab, enables analysis of metabolic heterogeneity at the single cell level. Marieke Ijsselsteijn Joana Nunes Noel F. de Miranda nature.com/articles/s4159…

Happy to share the 'Behind the Paper' on our recent publication about the integration of Imaging Mass Cytometry and Mass Spectrometry Imaging. Can't wait to see what the combination of spatial metabolomics and proteomics will teach us! de Miranda Lab communities.springernature.com/posts/spatiall…

.Tom van Wezel Stephanie Schubert @NfdeMiranda LUMC Leiden University of Dundee identify a heterozygous stop-lost variant in #TP53 that specifically affects p53β isoforms and predisposes to familial cancer #CancerResearch Cancer at Nature Portfolio nature.com/articles/s4146…

Exciting work led by Stephanie Schubert! We uncover a new variant of the beta isoform of the p53 gene linked to cancer risk. A STOP loss germline mutation increases its oligomerization with the main p53 isoform, affecting its function! #Genetics #Cancer

Great EORTC Soft Tissue and Bone Sarcoma Group Meeting in Turin! Thanks to all the attendees for the fruitful discussion!! Looking forward to future steps @winanvanhoudt Silvia Stacchiotti Alessandro Gronchi Alessandra Merlini Sarcoma UniTo Italian Sarcoma Group Paul Huang Lab de Miranda Lab EORTC