Moonshot preclinical update! We have good news to share. We have whittled down to a single advanced lead, DNDI-6510, after 6 months of intense work to optimize synthetic routes, and conduct ADMET-PK profiling, secondary pharmacology, and extensive virology... 🧵

The Centre for Medicines Discovery team in New York this week for the ASAP Discovery meeting. What a privilege to at last hang out with the people in person we were in the trenches with since COVID Moonshot. And getting to know all the new people joining our pandemic preparedness effort.

We are proud to be a part of the ASAP <asapdiscovery.org> Discovery team and do our best to pursue the development of new antivirals for future pandemics, (ASAP Discovery). Many thanks to John John Chodera (he/him) and the team for organizing this important meeting!

Moonshot has been a true global partnership since the start with over 400 scientists involved, and we're thankful to SCI – Where Science Meets Business💡 for recognizing these efforts! Drugs for Neglected Diseases initiative PostEra University of Oxford MedChemica John Chodera (he/him) Enamine Ltd 🇺🇦 Diamond Light Source

Several of Moonshot's leaders attended the event at the UK Parliament and came home with second place in the Innovation Award!

Elsevier is losing editors

An amazing open science effort - well done COVID Moonshot team!

This just has to be re-shared... and re-shared...

The next Open Antiviral Discovery forum is Wed 16 Aug at 11.00A ET, and features Thiago Moreno L. Souza (Center for Technological Development in Health, Fiocruz) and Melanie Ott (The Ott Lab of Gladstone Institutes) presenting! Register here: asapdiscovery.org/forum/#schedule

Spreading this here: 'Threatening the Future of Global Health — NIH Policy Changes on International Research Collaborations' nejm.org/doi/full/10.10…

#GoodNews for Global Antibiotic R&D Partnership (GARDP) "A new gonorrhea drug was developed by a non-profit foundation" And a reminder that the profit motive should have no place in healthcare, which should be run for public good economist.com/science-and-te…

New & impressive Science Magazine Here's how you discover a potent new drug vs Covid 212 scientists/15 countries Open-science, patent free, high-throughput structural biology based design, #AI COVID Moonshot Melissa Boby Frank von Delft Daren Fearon science.org/doi/10.1126/sc…

In the first-ever crowd-sourced research effort, the COVID Moonshot consortium has discovered a strong antiviral for #COVID. This result from @sciencemagazine will pave the way for potential antivirals for all coronaviruses. Centre for Medicines Discovery Discover more 👉 ndm.ox.ac.uk/news/covid-moo…

Extremely excited that our Moonshot story is now finally published in Science! science.org/doi/full/10.11…