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Scientists can now visualize the full spectrum of electrical communication between the human brain and cells in real time thanks to the development of a new genetically encoded voltage indicator called ASAP5 by Prof. Michael Lin and team at Wu Tsai Neuro. neuroscience.stanford.edu/news/new-volta…

Happy to be a part of this work with @autophagie1 team! Deepanshi Gahlot

#HighlightOfTheWeek Cosolvent molecular dynamics are an increasingly popular form of MD simulations where small molecule cosolvents are added to the system, helping to identify cryptic and allosteric pockets in proteins. #compchem pubs.acs.org/doi/10.1021/ac…

How plants use autophagy to selectively recycle chloroplast components under carbon limitation. elifesciences.org/articles/93232…

#PaperAlert we bring wonderful news about Women in Autophagy ... our Mericka McCabe and our founders just published a Nature Cell Biology article explaining the wonders of our Network...don't miss a bit!! With very valuables testimonials of our volunteers... nature.com/articles/s4155…

The world of cell surface receptors is truly incredible, as these molecules play fascinating roles in cell communication. Due to their considerable size (>2000 a.a), the structural details of these molecules remain partially uncovered by struc. bio. Thread about our recent paper:

New work from Lipi Thukral's and our group on insights from atomistic and coarse-grained MD and integrative modeling of Notch with its ligands. Great work led by Surabhi Rathore, collaborating with Deepanshi Gahlot, with Arastu Pandey and Shreyas Arvindekar. National Centre for Biological Sciences Tata Institute of Fundamental Research

A protein's position in the genome in relation to other genes is informative about function, so a genomic language model can be prompted to generate - toxin/antitoxin pairs - anti-CRISPR proteins + a database of 120B synthetic base pairs Aditi Merchant Samuel King Eric Nguyen Brian Hie

Two cells feeling each other out

A NOTCH closer to targeted therapeutics for cancer and developmental disorders: Rathore et al. use modelling and simulations to explore human NOTCH ectodomain dynamics, ligand interactions, and the impact of pathogenic mutations on signaling. ow.ly/JcEe50UKrJB

A new protein sequencing method, which uses a biological motor to pull a protein through a tiny nanopore, could revolutionise protein analysis. chemistryworld.com/news/nanopore-…

This time-lapse captures 17h of axonal growth from a chick dorsal root ganglion explant, seen through the actin cytoskeleton using live imaging. I just submitted this video to the Nikon Small World in Motion competition. Today is the last day to upload yours!😉 #neuroscience

In collaboration with Meera Sitaram's group we introduce a new discrete geometry-based method for integrative docking with chemical crosslinks (or other distance restraints). Work led by Yichi Zhang and Muskaan Jindal pubs.acs.org/doi/10.1021/ac…

Glad to see this published "Postnatal and juvenile fluoxetine treatment evokes sex-specific, opposing effects on mood-related behavior, gene expression, mitochondrial function, and dendritic architecture in the rat medial prefrontal cortex" doi.org/10.1016/j.biop….

Who knew #cholesterol transport could look this cool? Rendered in Blender 🔶 using #MolecularNodes Featuring #Apolipoprotein B-100 (RCSB PDB: 9BDT rcsb pdb 💉🧬💻🔬💊🌱🧠🦠) hugging a #lipid droplet, with #LDL receptors hitching all over. April 2025 Molecule of the Month #illustration #SciArt

CSIR-IGIB is thrilled to host a talk by Nobel Laureate Sir Paul Nurse, the First Director and Chief Executive of the Francis Crick Institute, on 26th May! Join us for an inspiring session with one of science’s greatest minds! souvik Chetana Sachidanandan CSIR, India HRDGCSIR

I made a tool called Diffusion Explorer that lets you to train and visualize simple 2D diffusion and flow models live in the browser. You can draw your own distributions and observe how the generated samples converge during training. Try it live 👇