First published chemical tool for depleting brachyury (TBXT) in cells is a major step forward in pursuing therapies against this target in chordoma and other cancers. Thanks for this important contribution ⁦Craig Crews⁩ &team + ⁦The Mark Foundation for Cancer Research⁩! pubmed.ncbi.nlm.nih.gov/38348945/

Excited to finally share the latest from the Crews lab! Craig Crews. Congrats to the whole team Adrian Bebenek , Pengju Nie, and others. Check out our story on targeting transcription factor brachyury below!

Yale Molecular Biophysics and Biochemistry beats Auburn Basketball 78-76, talk about March madness!

I’m thrilled to share our recent work on dual inhition of EGFR with PhosTAC. Congrats to the team POHAN CHEN, Wenxue, Sisi Zheng, Jacques Saarbach, Ines and John. And we are deeply grateful for the great mentorship from Yansheng Liu and Craig Crews! science.org/doi/10.1126/sc…

Design and Application of Cereblon-Recruiting Prodegraders | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Introducing prodegraders: a new approach to access glutarimides via cyclization. Built on a lot of great work in the TPD field. Thanks to the great team! pubs.acs.org/doi/10.1021/ja…

Design and Application of Cereblon-Recruiting Prodegraders | Journal of the American Chemical Society Yale University pubs.acs.org/doi/10.1021/ja…

Design and Application of Cereblon-Recruiting Prodegraders Reference pubs.acs.org/doi/10.1021/ja… J. Am. Chem. Soc. Top Science #Chemistry #chemed #scicomm #news #Technology #Tech #TIC2025 #research #science #AcademicTwitter