💧Fluid restriction in #HeartFailure, myth or must? Current guidelines offer limited evidence & FRESH-UP study fills the gap with real-world data on fluid & sodium strategies Join our #HFA_ESC Journal Club and: ✔️Understand the rationale, study design & findings ✔️Discuss

Is there a publication?

This should be the end of AI mania. They can be made to say anything that their owner wants. But there is so much money behind AI, and so many gullible politicians believe the hype, that the scandal will blow over soon.

NEW PAPER in The BMJ "Dealing with continuous variables and modelling non-linear associations in healthcare data: practical guide" --> bmj.com/content/390/bm… #methodologymatters

The Leng Review - the independent review of the physician associate and anaesthesia associate roles - has now been published. We know many of you have been waiting for these findings to be announced. We really understand just how important this issue is. (1/2)

Outstanding paper! Especially suited for non-statisticians who want to get started with relaxing linearity assumptions without resorting to dreaded categorization techniques ... @Statistics

This paper is largely based upon legacy studies. Studies before the wide spread use of PCI in STEMI and non-STEMI patients. The rate of PCI was not reported. This paper is an academic exercise and should not change practice. PCI stratification is helpful.

This paper has very important implications for clinical practice. Most biological systems are not linear. They are a S shaped curve.

Madness. Duke School of Medicine is incentivizing bad science and dishonesty. The bosses are destroying their own institution, I just hope it doesn't kill anyone -they haven't learned from Stefan Grimm -seev dcscience.net/?s=Grimm

Difficult to make efficacy statements from a cohort study.

We need a larger study which shows improvements in hard clinical endpoints. Then upfront heparin can be the standard of care.

A linear regression should not be used. A fractional polynomial mathematical model should be applied. Most biological systems are not linear instead they are S shaped curves.

When modeled with fractional polynomials rather than a simple cut off, post PCI creatinine shows a smooth non-linear relationship with long term MACE. This pattern suggests CA-AKI is often related to underlying health rather than an independent marker.

Impact of LVEF on the effect of beta-blockers on 1-year mortality in patients with acute coronary syndrome. New evidence from the AMIS plus registry published in #EHJPharmacotherapy 🔍📝 ow.ly/YgsE50WIPYV EHJ-CVP Editor-in-Chief Felice Gragnano Mattia Galli

Angina with non-obstructive coronary arteries: a success story. Read more in #EHJ 👉 ow.ly/zwfb50WT4kW Rocco Montone EHJ Editor-in-Chief #ANOCA

The evidence is weak for Class 1B since some of the studies had about 25 percent lost to follow up and missing data. A study with more than 20 percent lost to follow up is not informative nor reliable and should not be used by guideline committees.

We need statisticians on our guideline committees.

Invictus by William Ernest Henley Out of the night that covers me,       Black as the pit from pole to pole, I thank whatever gods may be       For my unconquerable soul. In the fell clutch of circumstance       I have not winced nor cried aloud. Under the bludgeonings of

Apologies that fpr-calc.ucl.ac.uk is unavailable at the mo. It's waiting for DNS update to spread following a redirect. Meanwhile you can run the false positive risk calculator at davidcolquhoun.shinyapps.io/fpr-calc-ver1-… See onemol.org.uk/?page_id=456 for more on #statistics

The US government has not stopped funding PubMed. Temporary shutdown. It may not be up to date.