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New paper → Is inflammatory signaling involved in disease-related muscle wasting? Evidence from osteoarthritis, chronic obstructive pulmonary disease and type II diabetes sciencedirect.com/science/articl…

Cardiotoxin-induced skeletal muscle injury elicits profound changes in anabolic and stress signaling, and muscle fiber type composition. dlvr.it/Rb3LRL

New paper with Evelien Van Roie, PhD Stijn Bogaerts Ruud Van Thienen: Omega-3 supplementation improves isometric strength but not muscle anabolic and catabolic signaling in response to resistance exercise in older adults academic.oup.com/biomedgerontol… Gerontological Society of America (GSA) Oxford Journals Aging Science News

Journal of Muscle Research and Cell Motility has a new Special Issue with a lovely cover image coming from Dalle et al : Cardiotoxin-induced skeletal muscle injury elicits profound changes in anabolic and stress signaling, and muscle fiber type composition rdcu.be/cbY1I

When lab work is satisfactory.

Public PhD defense of Sebastiaan Dalle -𝗜𝗻𝗳𝗹𝗮𝗺𝗺𝗮𝘁𝗼𝗿𝘆 𝘀𝗶𝗴𝗻𝗮𝗹𝗶𝗻𝗴 & 𝗺𝘂𝘀𝗰𝗹𝗲 𝗽𝗹𝗮𝘀𝘁𝗶𝗰𝗶𝘁𝘆 - 𝗮 𝗱𝘂𝗮𝗹 𝗿𝗲𝗹𝗮𝘁𝗶𝗼𝗻𝘀𝗵𝗶𝗽- When: Thursday, May 27th, 2021 Start: 16h00 Livestream: bit.ly/3bi0YmQ

Cannabinoid receptor 1 (CB1) is more abundant in type I fibers & CB2 is more abundant in type II fibers. More characteristics of CB expression in human muscle in our latest work: doi.org/10.1038/s41598…

New data presented on protein expression patterns in older adults with low vs. preserved muscle strength: satellite cell regulators & stress signaling appears to be crucial! ICFSRcongress

The active grandparent hypothesis: Physical activity and the evolution of extended human healthspans and lifespans pnas.org/content/118/50…

Cannabinoid mediator (ligand, enzyme & receptor) expression is altered in circulating and peripheral (muscle & adipose) tissue of sarcopenic vs. adult rats: Target / marker of (age-related) muscle degeneration? onlinelibrary.wiley.com/doi/10.1002/jc…

↑ myogenic (Pax7, MyoD, desmin) and ↑ stress (CHOP, pERK) (but ↓ p-p65?!) expression in muscle of older adults with low muscle strength. Yet, potential confounding by diet/PA levels. Nice collab with the Geriatric Medicine UZ Leuven FWO doi.org/10.1093/gerona…

Molecular networks underlying cannabinoid signaling in skeletal muscle plasticity | Sebastiaan Dalle et al. | Review #myotwitter pubmed.ncbi.nlm.nih.gov/35862111/

Thanks for sharing! Experimental data following soon I hope!

The peripherally restricted CB1 antagonist AM6545 stimulates in vivo muscle protein synthesis and Akt-mTOR axis (in TA & Gastr, not in SOL which is higher in CB1?) → protect against dexamethasone-induced muscle loss sciencedirect.com/science/articl…

The CB1 antagonist Rimonabant induces pro-regenerative, anti-inflammatory & anti-apoptotic muscle adaptations, as well as thorough lipid remodelling. Changes beyond metabolic control, suggesting novel therapeutic applications. KU Leuven Movant sciencedirect.com/science/articl…

After 65 days I leave this nice laboratory! Thanks Louise Deldicque and Marc Francaux for the wonderful opportunity!

The Role of Inflammation in Age-Related Sarcopenia: Sebastiaan Dalle, Lenka Rossmeislova, Katrien Koppo goo.gl/mbHWvA

The Role of Inflammation in Age-Related Sarcopenia | Review 💪🏼🧓🏼👵🏼 frontiersin.org/articles/10.33…

A non-interfering system to measure in-cage spontaneous physical activity in mice | Chiel Poffe Peter Hespel physiology.org/doi/abs/10.115… #JAPnew #ArticlesInPresS #physiology #PhysicalActivity