⏰Six days to go, in person registration closes 10 June - 2024 Annual Meeting, spread the word! trophoblast.cam.ac.uk/ctrconferences…

Really looking forward to this meeting!

We are delighted to announce that Professor Edith Heard has been appointed as our new director and chief executive! Edith, who is currently director-general at @EMBL, will succeed Paul Nurse in leading the Crick from the summer of 2025. 🔗 crick.ac.uk/news/2024-07-0…

Interesting observation from Trey Ideker and colleagues: could #epigenetic ageing clocks reflect somatic mutation rather than cellular reprogramming? Good rule of thumb: whenever there's an "epigenetic" change, look for a genetic change. biorxiv.org/content/10.110…

I’m really excited to share our research, which exploits an ESC model, chimeric embryo experiments and single-cell multiomics to uncover a role for TF Eomes in regulating extra-embryonic Mesoderm (ExEM) patterning at the onset of mouse gastrulation. 🧵👇 biorxiv.org/content/early/…

Postdoctoral Research Associate position available in the laboratory of Dr. Irving Aye, Department of Obstetrics & Gynaecology, University of Cambridge, UK, to study how metabolism influences placental development. For more information and to apply: jobs.cam.ac.uk/job/47976/

It is challenging to study the ability of transcription factors to engage their motifs in the cell. We tried to address this in our new study together with Marco (Marco Pregnolato), Schübeler Lab, and FMI science: cell.com/molecular-cell…

The inner lining of the uterus, the endometrium, has been mapped during multiple phases of the menstrual cycle 🔎 Researchers have uncovered diverse cell types and processes, including some that may have a role in conditions such as #endometriosis sanger.ac.uk/news_item/huma…

We are absolutely delighted to announce that the Centre for Trophoblast Research has been named in honour of Professor Charlie Y.W. Loke! Read more about the Loke Centre's new name on our website: tinyurl.com/LokeCTR

Wang, H., Huang, Z., Shen, X. et al. Rejuvenation of aged oocyte through exposure to young follicular microenvironment. Nat Aging (2024). nature.com/articles/s4358…

Excited to announce the speaker lineup for 2024-2025!

I am looking forward to this one! :) Thanks for the invitation!

We have put together an exceptional scientific programme for the The Genetics Society #Epigenetics2025 meeting to be held in Belfast. Are you interested in disease mechanisms and love epigenetics? Register here: REGISTER ONLINE: my.genetics.org.uk/item.php?event….

A spatiotemporal transcriptomic atlas of mouse placentation😍 nature.com/articles/s4142…

Happy to see this was published yesterday! It was great working on this with Shankar and Shifaan Thowfeequ. And thank you to the great editorial team at Nature Reviews Molecular Cell Biology.

Nucleosomal asymmetry shapes histone mark binding and promotes poising at bivalent domains sciencedirect.com/science/articl…

Using single-cell RNA-seq + PBAT, we characterised the molecular profiles of NSN and SN GV oocytes, which show highly distinct chromatin structures (example below). A great collaboration!