It’s been brilliant setting up my lab in Sheffield! So much to do, and the Peak District on our doorstep will surely be distracting!

I am super excited to show our work, now published in NAR Nucleic Acids Res, on the structural function of SLF1 at the stalled replication fork. The Astbury Centre @ScienceLeeds academic.oup.com/nar/article/do…

BBC weather seems a bit confused… Hope everyone is ok in Florida…

Exciting! Meeting all my colleagues working on SMC complexes in Numazo Japan: niki-lab.sakura.ne.jp/NIGIS2024/inde…

Brilliant to be in Japan at the SMC meeting presenting my work on Condensin regulation! Huge thanks to The Company of Biologists and BSCB for a travel grant to help me get here!

New work from the lab! James Stowell led this project showing the importance of multivalency and phospho-regulation in mRNA decay. This has many parallels with other mechanisms in gene expression... 🧵 1/ #RNA #NMR #bioRxiv @MRC_LMB European Research Council (ERC)

🔥JOB ADVERT🔥 Looking for a postdoc to work on #machine_learning classification of #knots & #proteins and discovery of new topological invariants. Start by November 2025 Duration 2 years min Where: TAPLab Physics Astro @ Edin Generously funded by The Leverhulme Trust Retweet pls ❤️

A quantitative intracellular peptide binding assay reveals recognition determinants and context dependence of short linear motifs biorxiv.org/cgi/content/sh… #biorxiv_biochem

Very proud of Boya Zhang and this lovely first paper, first of many I am sure.

Excited to share that the AlphaFold 3 model code and weights are now available for academic use. Looking forward to seeing what new research this unlocks and how the research community builds on AlphaFold 3 for scientific discoveries github.com/google-deepmin… 1/2

“We’re very excited to see what people do with this” AlphaFold3 is open at last go.nature.com/4fHAfio

The short talk abstract deadline for the Keystone Interplay of Chromatin Architecture and Transcription Regulation meeting is coming up (Jan 9). The meeting is being held jointly with the Epigenetics in Development and Disease meeting, and it will be awesome! #KSChromatin25

Trying to get multiple manuscripts published at the same time:

Our work on SMC Wadjet complex is finally out Molecular Cell ! Congrats to @BisLightyear Amar Deep Kevin Corbett & co.!

There is nothing like seeing an article online!

🚨We’re hiring! Passionate about #microscopy, #biophysics and #interdisciplinaryresearch? There's still time to apply for our EPSRC PhD project on how actin network architecture shapes the mechanical properties of cells at The University of Sheffield Learn more/Apply: findaphd.com/phds/project/f…

The study of KIF4A-mediated human condensin I activation is out! Congrats to Dr. Erin E. Cutts 👩‍🔬, L. Aragon, Damla Tetiker !