Congratulations to Tiantian Cui MD, PhD for leading rigorous work on our novel albumin-gemcitabine prodrug JNTX-101, now published in Molecular Therapy Oncolytics, that she previously presented at AACR. ASGCT AACR City of Hope sciencedirect.com/science/articl…

We are very excited to be able to offer this innovative, cutting-edge, treatment to our patients!

Here, Terry Williams discusses the potential of #SCINTIX PET-guided #BgRT to address unmet need in the future and bringing more biology to the treatment of cancer in #radonc. City of Hope bit.ly/48r0Rji

Congrats to Adam Wolfe, MD, PhD, Tiantian Cui MD, PhD, and the rest of the stellar team for the Science Advances publication on nutrient scavenging in #pancreaticcancer. 👏 The work uncovers a pivotal role for caveolae-mediated endocytosis (CME) in fueling #PDAC growth. #pancsm #gism

2/n In this report, CAV1 is found to be associated with the most aggressive molecular subtypes of #PDAC, including basal-like, quasi-mesenchymal, and squamous using the Moffitt, Collisson, and Bailey schemes. PanCAN Lustgarten Foundation Anirban Maitra

3/n Not surprisingly, high CAV1 gene expression is significantly associated with worse overall survival in multiple datasets.

4/n Proteomic profiling revealed Cav-1 was overexpressed in higher grade #PDAC and associated with worse clinical outcomes in our own institutional dataset, and higher Cav-1 expression was detected in serum and metastases in patients with metastatic #pancreaticcancer.

5/n We developed the first conditional knockout mouse model of CAV1, and genetic of Cav-1 in this GEMM in the #KRAS KPC mouse model significantly attenuated #PDAC growth and reduced tumor burden. KRASKickers

6/n We observed significant differences in #tumor cell growth capacity in CAV1 depleted tumor cells in low nutrient depleted conditions (1% FBS).

7/n Delving deeper, we found phenotypic alterations in #tumor #metabolism, with defects in glycolysis and #mitochondrial metabolism in cells depleted of Cav-1. These defects were pronounced under nutrient depleted conditions.

8/n We established that Cav-1/CME is a critical mediator of #glutamine uptake, and that CME-mediated uptake of #albumin likely serves as an important source of glutamine in these cells.

9/n Finally, we elucidate that Cav-1 mediated regulation of ribosomal S6 under conditions of nutrient stress are likely contributing to tumor growth and survival through ribosomal translation.

10/n Together, these results establish a critical role for Cav-1/CME in fueling #pancreaticcancer growth through nutrient scavenging and enhanced #tumor #metabolism, providing more support for targeting this pathway. 🙏to all the fantastic scientists & patients who contributed❗️

Fantastic science, talks, and discussions Gordon Research Conferences in DNA Damage, Mutation, and Cancer (DDMC) this past week in the beautiful Ventura, led by wonderful Chair & Vice Chair team of Jeremy @jstarklab and Shan Zha Zha Lab ❗️🧪 Thanks for putting this together.

.Simon Powell, Meredith Morgan, Tiantian Cui, and Gaorav Gupta discussed "Integrating DNA Damage Repair Targeting with Radiation Therapy" in a plenary at the AACR Conference on Translating Targeted Therapies in Combination with Radiotherapy. #AACRradiation25 Gaorav Gupta

What a fantastic #AACRRadiation25 conference in San Diego with a stellar lineup including our own Tiantian Cui MD, PhD and Dr. Ghomalin. 🙏 to Quynh Thu Le Albert Koong, MD PhD & Silvia Formenti for putting together a great session to discuss where the future of RadOnc needs to go.#radbio