Excellent work Takahashi et al. Embryonic genome instability upon DNA replication timing program emergence nature.com/articles/s4158…

Excited to share our lab's latest research, out today NatureStructMolBiol, which describes how 53BP1 controls DNA Repair in class-switching B cells & BRCA1 mutant cancers. Final article can be found here: nature.com/articles/s4159…; & the following thread walks you through the details

Our latest paper -> On identifying the mutations driving clonal hematopoiesis using machine learning models - BoostDM-CH Great team work by Santi Demajo Meseguer, Joan Enric Ramis Z, Ferran Muiños et al Tweetorial 👇

My department at Oxford is hiring - Assistant/Associate professor level positions at Ludwig Cancer Nuffield Department of Medicine. Broad interests in cancer cell plasticity, epigenetics, epitranscriptomics, microenvironment but all areas considered. Check out ad here: nature.com/naturecareers/…

Applications close tomorrow for a seriously good looking postdoc with Duncan Odom at DKFZ. jobs.dkfz.de/en/jobs/166889…

Excited to share my first paper from grad school is out today! Mutations can affect the short-term fitness of an organism, as well as the rates and benefits of future mutations. We asked: how do these pressures balance in microbial populations? nature.com/articles/s4155…

It's even more braided than you think, @maureenmkearney et al! Genomic studies show many species remain distinct in spite of abundant introgression. "Tangled banks, braided rivers, and complex hierarchies: beyond microevolution and macroevolution" doi.org/10.1093/jeb/vo…

FOUR modified RNA bases read out in one command with the latest Dorado release. Enabling so much greater exploration of RNA biology! #NanoporeConf

📢We are moving to Yale University University! - very grateful to everyone Cambridge University and Yale School of Medicine who is helping with our multifaceted move… Want to be part of Aitken Lab 2.0? We are hiring at all levels - so get in touch!

Estimation of demography and mutation rates from one million haploid genomes biorxiv.org/cgi/content/sh… #biorxiv_genomic

I am happy to share our new preprint led by two briliant junior researchers, Long Wang Long Wang and Christo Morison, on a gene-for-gene model in cancer immune coevolution. biorxiv.org/content/10.110…

We are thrilled to announce two open rank faculty searches U of Utah Human Genetics: a broad search for all areas of genetics research (utah.peopleadmin.com/postings/170913) & one focused on computational genomics faculty (utah.peopleadmin.com/postings/170449). This launches a multi-year recruiting initiative! (1/4)

Fast and Accurate Estimation of Selection Coefficients and Allele Histories from Ancient and Modern DNA buff.ly/4gksMXr #science #evolution #biology #genome

Immune surveillance of cancers is thought to be an important force shaping tumour evolution. Is the same true of somatic evolution in general? Does the adaptive immune system “see” non-self clonal expansions and eliminate them? A:👇 by Babrara Walkowiak biorxiv.org/content/10.110…

I'm excited to share that our team at Inocras has posted our whole-genome analysis of 1,364 breast cancer cases—the largest cohort with clinical records to date. Many thanks to our collaborators at Samsung Medical Center and Seoul St. Mary's Hospital. doi.org/10.21203/rs.3.…

'Defining precancer: a grand challenge for the cancer community' nature.com/articles/s4156…

What is the most common type of mutations, causing cancer and genetic diseases? C to T mutations in CpGs: Signature 1. What is the best understood mutational signature? Signature 1. Or is it? Results of over 8 years of our work is finally out! 🧵1/ nature.com/articles/s4158…

🌟NEW PREPRINT ALERT!🌟 We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution” biorxiv.org/content/10.110… [1/12]

Such a rad paper, congratulations!!

Would you like to do some unique experiments in cancer genomics and mutagenesis, in beautiful Munich? Well then apply for this PhD position: jobs.dkfz.de/en/jobs/167996… You'll learn a lot and it'll be fun and interesting! #DKTK DKFZ Universität München