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Our paper, "Metabolic enzymes aldo-2 and pdhb-1 as potential epigenetic regulators during C. elegans embryogenesis" is out now :D Thanks Sonia Ravanelli, Ferdinand von Meyenn, Collin Ewald, Chantal Wicky micropublication.org/journals/biolo…

Registration closes this Friday, 21 June! 📣 We are looking forward to welcoming you in #Mainz next week. ➡️ imb.de/dgfa2024 #alternsforschung #ageingresearch

This study raises the possibility that the effect of #IIS and related pathways on resilience and frailty during aging in higher animals might possess some degree of reversibility. GeroScience 🍬🔬👵 Adrian Molière Collin Ewald et al. link.springer.com/article/10.100…

It’s never too late: Our new paper explores how auxin-mediated DAF-2 degradation still massively extends lifespan even at a very old age. A short 🧵 #Aging #GeroScience #AgingResearch link.springer.com/article/10.100…

Big thanks to GeroScience, Collin Ewald, and all the collaborators for this amazing project: @ParkisLaelaps, Anita M, Elena M Vayndorf, Bruce Zhang, Kuei Ching Hsiung, Yoonji Jung, Sujeong Kwon, Cyril Statzer, David Meyer, Richard Nguyen, Joseph Chadwick, @Max_t88

Kudos to Adrian Molière, @ParkisLaelaps, and the team for pushing this over the finish line. I'm so happy this work got published! It looks like end-of-life doubling of lifespan upon daf-2 degradation potentially via restoring #protein #homeostasis.

How To Choose a Good Scientific Problem (1/3)

Quality of supplements targeting aging: Testing the amount of nicotinamide mononucleotide and urolithin A as compared to the label claim | GeroScience (springer.com)

📢New Open🔓Access Article Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age by Adrian Molière & Collin Y. Ewald (Collin Ewald) et al. rdcu.be/dME0d #endoflife #frailty #insulin #IGF1 #longevity #proteinhomeostasis #resilience

Roles for matrix/basement membrane proteins nidogen and laminin in sensing touch. C. elegans touch receptor neurons direct mechanosensory complex organization via repurposing conserved basal lamina proteins sciencedirect.com/science/articl…

@LucaGiorgetti Juanma Vaquerizas And now nicely formatted here: rdcu.be/dOxQs

Congrats to Peter Meister’ s lab. Condensin I folds C.elegans folds genomes. nature.com/articles/s4158…

#ARDD2024 Collin Ewald at ARDD2024: Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age youtu.be/2APxO5Tr8Z4

Exciting science on your end-of-year wish list?!? >> apply to our postdoc and PhD positions and start 2025 with a new job Universität Basel

Wonderful talk by Jan Gruber who was able to model a mystery from my former lab. If its all damage accumulation, how can the lifespan of C. elegans be doubled at the end of life? A physics derived model can explain it! youtu.be/pXFE_dcDIDc?si…

Targeting DNA damage in ageing: towards supercharging DNA repair, read now our latest article in Nature Portfolio Nature Reviews in Drug Discovery. Arturo Bujarrabal Dueso George Garinis Paul Robbins Jan Vijg CECAD Cologne Uniklinik Köln Free access to the article here: rdcu.be/eqK9r

New BSRA seminar incoming! On June 26 at 4pm UK time, we’re joined by Dr Della David (Babraham Institute) for a deep dive into: “Strategies to Mitigate Age-Dependent Protein Aggregation” Free + open to anyone interested in ageing biology. bsra.org.uk/events/seminar…

New brief on the Biology of Aging is out by the United Nations. Honored to be a Scientific Board Member. un.org/scientific-adv…