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CD47 × PD-L1 bispecific antibodies boost tumor-resident CD8+ T cell responses, enhancing anti-tumor immunity and highlighting dual checkpoint blockade as a promising cancer therapy Australian and New Zealand Society for Immunology Wiley onlinelibrary.wiley.com/doi/full/10.10…

Reduced IL34 in squamous cell carcinoma disrupts Langerhans cell function and spatial organization, impairing local immunity and correlating with poorer survival outcomes. Australian and New Zealand Society for Immunology Wiley onlinelibrary.wiley.com/doi/full/10.10…

Older patients generate fewer, more differentiated CAR T cells, and activation protocols impact yield and quality, highlighting the need for tailored manufacturing strategies to optimize outcomes in this population. Australian and New Zealand Society for Immunology Wiley onlinelibrary.wiley.com/doi/full/10.10…

Type 2 epithelial cytokines and basophils play critical roles in allergic inflammation and immune responses, with recent FDA-approved biologics targeting these pathways offering new treatments for allergic diseases. Australian and New Zealand Society for Immunology Wiley onlinelibrary.wiley.com/doi/full/10.10…

Incorporating non-criteria antibodies improves obstetric antiphospholipid syndrome diagnosis, identifying cases responsive to aspirin/heparin therapy despite low traditional aPL levels Australian and New Zealand Society for Immunology Wiley onlinelibrary.wiley.com/doi/full/10.10…

Off-the-shelf CD19-CAR double-negative T cells show promising efficacy, safety, and manufacturability for treating haematological malignancies, with no observed immunotoxicity or GVHD Australian and New Zealand Society for Immunology Wiley onlinelibrary.wiley.com/doi/full/10.10…

Autoantibodies against CD209/CD209L are found in some COVID-19 patients but aren't linked to worse outcomes, unlike anti-ACE2 and anti-IFNα antibodies. onlinelibrary.wiley.com/doi/full/10.10… Australian and New Zealand Society for Immunology Wiley

BCG induced a broad and persistent reduction in ex vivo cytokine responses to SARS-CoV-2 but had no impact on antibody or T-cell responses to COVID-19 vaccines. Australian and New Zealand Society for Immunology Wiley onlinelibrary.wiley.com/doi/full/10.10…

CAR therapy faces challenges with high relapse rates (~60%), off-tumor toxicity, and immune deficits—organ-on-chip tech offers a promising alternative to animal models for real-time testing Australian and New Zealand Society for Immunology Wiley onlinelibrary.wiley.com/doi/full/10.10…

Lower dendritic cell levels in blood and airways predict severe COVID19, while monocytes accumulate in the lower airways. DC depletion persists in severe cases, but most immune responses recover post-infection Australian and New Zealand Society for Immunology Wiley onlinelibrary.wiley.com/doi/full/10.10…

MAIT cell activation profiles in the emergency department distinguish sepsis severity, with high CD69 expression linked to worse outcomes and cytokine-driven activation Australian and New Zealand Society for Immunology Wiley onlinelibrary.wiley.com/doi/full/10.10…

We warmly congratulate Dr Charis Teh - winner of the Margaret Baird Women in Immunology ASI Award!! WEHI (Walter and Eliza Hall Institute) #IWD25 Read more here: immunology.org.au/blogs/Latest-N…

Long-term γδ T cell reconstitution after allogeneic stem cell transplantation shows a normalised repertoire, sustained CMV control, and increased activated Vδ1+ T cells in severe chronic GVHD Australian and New Zealand Society for Immunology Wiley onlinelibrary.wiley.com/doi/full/10.10…

Progressive loss and activation of MAIT cells correlate with worsening myocardial ischaemia and remodelling in CAD patients, possibly due to gut microbial leakage Australian and New Zealand Society for Immunology Wiley onlinelibrary.wiley.com/doi/full/10.10…

Radiotherapy can boost T-cell responses and enhance immunotherapy, but clinical success remains limited—future research must address barriers and optimize combinations for better cancer outcomes Australian and New Zealand Society for Immunology Wiley onlinelibrary.wiley.com/doi/full/10.10…

IgG aggravates TNF-α-mediated osteoclastogenesis by enhancing TNFR1/NF-κB signaling, helping explain the greater joint damage seen in RA compared to SLE. Australian and New Zealand Society for Immunology Wiley onlinelibrary.wiley.com/doi/full/10.10…

T-cell responses to SARS-CoV-2 spike differ after vaccination vs. natural infection—vaccines focus on limited regions and HLA-A, while infection broadens epitope spread and shifts to HLA-B (esp. B7) Australian and New Zealand Society for Immunology Wiley onlinelibrary.wiley.com/doi/full/10.10…

In posterior uveitis, vitreous T cells—especially polyfunctional CD8+ cells—show distinct, antigen-specific responses not mirrored in blood, highlighting the limitations of PBMCs in reflecting ocular immunity. Australian and New Zealand Society for Immunology Wiley onlinelibrary.wiley.com/doi/10.1002/ct…

Lower B cells and Tregs—seen before transplant—were linked to chronic lung allograft dysfunction, not donor-specific antibodies. High-dimensional flow cytometry reveals early immune clues. Wiley Australian and New Zealand Society for Immunology onlinelibrary.wiley.com/doi/10.1002/ct…

Public scRNA-seq data are key to paediatric cancer research, but poor deposition standards hinder reuse. A review of >1.3M cells from 488 samples proposes a framework to improve practices. onlinelibrary.wiley.com/doi/10.1002/ct… Australian and New Zealand Society for Immunology Wiley