I’m amazed by Yohan J. John and his patience for boxing with the bears he pokes… I nominate him as Twitter champion of mechanistic modelers in neuroscience (unofficial).

Incrementalism in science is also sexy. Too many knowledge pyramids are being built from the capstone down.

Are we witnessing the dawn of post-theory science? “Does the advent of machine learning mean the classic methodology of hypothesise, predict and test has had its day?” Add me to the list of those deeply uncomfortable with the trend. apple.news/AhoInZwBXSvOoP…

When Mind Melds With Machine, Who’s in Control? buff.ly/3GuBY9D Lay-accessible discussion of BCI ethics with brilliant early career cortical networks scientist and emerging #scicomm -er, @kellybclancy Worthwhile read for established neuroengineers too.

I was struck by this quote: “…we can run endless simulations on the computer until we find what we need” In my experience, you can find Atlantis in a model that is complex and under-constrained enough… wired.com/story/the-ques…

My favorite science advice to ignore: “That’s not interesting…you should do [insert trendy topic], instead.” I’m a scientist because of my own interests, thank you very much.

Had a cool paper accepted today in JNP …looking forward to a tweet series as soon as it goes online. Long/short: Of course DBS activates the hyperdirect pathway…it just likely gets capsular fibers too. So, how do we tell the two apart with evoked potentials?

#ArticlesinPress - "Subthalamic Deep Brain Stimulation of an Anatomically Detailed Model of the Human Hyperdirect Pathway" Clayton Scott Bingham and Cameron C McIntyre #DBS #Axon #Neuroscience Duke University ow.ly/mw7k50Iqq9a

“We developed Comprehensive Analysis of Tissues across Scales (CATS),…to densely map brain tissue architecture from millimeter regional to nanoscopic synaptic scales in diverse chemically fixed brain preparations, including rodent and human” biorxiv.org/content/10.110…

Pilot study of responsive nucleus accumbens (NA) deep brain stimulation for loss-of-control eating “[When] the device sensed NA signals that had been found to predict food cravings, it automatically stimulated that region, disrupting the craving signals” nature.com/articles/s4159…

Bad title, good article. At the end of the day, one problem is easier than three & small topics are easier than large. Reality: Too many “day one” trainees think they should shake up a group with a flurry of new ideas. Unlikely as it is unproductive. insidehighered.com/advice/2022/09…

Reduced Thalamic Excitation to Motor Cortical Pyramidal Tract Neurons in a Mouse Model of Parkinsonism “reduced motor cortical outputs in PD are an immediate consequence of basal ganglia inhibition but also involves local circuitry adaptations within M1” biorxiv.org/content/10.110…

Workshop opportunity! Interested in using neural stimulation & brain recordings to understand brain function? Register for this #BRAINInitiative 2-day virtual workshop, exploring progress made, challenges to overcome, & potential impact. #studyBRAIN go.nih.gov/rBavITh