Now online! SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress dlvr.it/TM4dlf

I find trinucleotide repeat disorders fascinating; between this new paper from Raghu Chivukula, MD PhD 🫁🧬🧠 on GGC repeats and one earlier from Steve McCarroll on CAG repeats (x.com/s_mccarroll/st…), we're seeing some real bangers this year starting to dissect the mechanisms of pathogenesis

Excited to announce that this work is now live as a first release article Science Magazine So grateful for this fantatic team and to see this work in wild! science.org/doi/10.1126/sc…

Excited to share our new preprint on bioRxiv from our great team @EMBL! biorxiv.org/content/10.110… If the nucleolus is liquid-like, why does it often appear irregularly shaped in proliferating mammalian cells? What controls the nucleolar shape? #PhaseSeparation #Nucleolus

Practicing knot tying is underemphasized in the training of those in non-surgical specialties. Many years of observation has shown that any discomfort in tying knots will add *significantly* to the overall cognitive burden of doing a procedure. The goal is to get rid of this.

One lesson of DOGE is that a lot of federal govt spending is sent to old ppl (social security, Medicare) and affluent individuals/orgs (defense, health spending) but the spending with the highest “lives saved per dollar spent” tends to go to v poor people or to scientists working

Our paper on discovering a new paradigm in peroxisome biogenesis and PEX39 (1st human peroxisomal biogenesis protein found in > 20 yr) is out in Nature Cell Biology! Wonderful, equal collab with Tony Rodrigues, Dwendscheck (dwendscheck.bsky.social), Jorge Azevedo, Warscheid lab nature.com/articles/s4155…

Yet another beautiful piece of structural and biochemical work led by by friend, colleague, and MassGeneral Medicine resident Max Valenstein, MD, PhD! Thrilled to have contributed in a small way to this important study. Congrats to Pranav Lalgudi, David M. Sabatini, Kacper, et al. nature.com/articles/s4158…