Ad!! Iván is looking for grad students/postdocs now at UTSW Media Relations ….the lab has two great gene regulation stories that will be published soon with exciting preliminary data for others to follow up on. Gene regulation folks, please retweet to spread the message!

Excited to share a small part of my PhD work with Ivan D’Orso: We used CRISPR-Cas9 to create a HIV-1 cell system that does not express Tat. We expect this model to assist in mechanistic characterization of signal-induced HIV-1 latency reactivation. mdpi.com/1999-4915/16/2…

Our recent paper building a new tool to study HIV-1 transcription is highlighted here: utsouthwestern.edu/newsroom/artic… Ivan D’Orso UT Southwestern Medical Center UTSW Graduate School of Biomedical Sciences

UT Southwestern Medical Center This work would not have been possible with support from many people. Namely, Ashwini Challa who experimentally supported the project the whole way through, and the W. Lee Kraus lab Tulip Nandu and Twitterless Micah Thornton (who developed Proxy Rate!)

My review about “The HIV-1 transcriptional program” for the Journal of Molecular Biology special issue on transcription elongation is now out: doi.org/10.1016/j.jmb.…. I provide a 4 decades historical recount from mechanistic insights to implications for viral latency and cure. Thanks @NIAID!

Our paper highlighting the counterintuitive importance of negative regulation of transcription elongation to facilitate full gene activation during cell fate decisions is out: nature.com/articles/s4146…. Congrats Usman Hyder and Ashwini Challa and the collab with the Kraus Lab

Our new study by Jinli Wang and Ivan D’Orso at @UTSW is out. We reveal the importance of the ARF tumor suppressor in dismantling transcription elongation complexes to selectively disable oncogenic transcription programs upon p53 loss. Great collab with Seychelle Vos and others, National Cancer Institute.