Online Now: Integrator endonuclease drives promoter-proximal termination at all RNA polymerase II-transcribed loci dlvr.it/SbsRkq

Thrilled to see the last few bits of data from my doctoral work now out nature, right in time for Thanksgiving !! Thanks to Leonie Uhl & @Daniel_Solvie for sharing the lead on this :) We found out how cancer cells use MYC to deal with the stressful tumor environment.Thread:

Online Now: Integrator is a global promoter-proximal termination complex dlvr.it/Sgk2zj

Congrats to my colleagues (particularly Ben and Eileen) on this incredible work! Tons to think about in terms of chromatin, transcription, and their connections to cancer biology.

I may be biased, but Hanneke is an incredible scientist and mentor. Run, don't walk, to her new lab!

Excited to share the last part of my PhD work, where we track co-receptor signaling dynamics during B cell activation! Great collaboration with Marian Kalocsay biorxiv.org/content/10.110…

Huge congrats to Claudia on her incredible story on U1 and RNAPII elongation rate being published! It's been so much fun watching it develop over the last few years. Be sure to check out her Tweetorial and paper!

Congratulations to Harvard Med BCMP faculty member Karen Adelmen for her election to the American Academy of Arts and Sciences!  AdelmanLab Harvard Medical School

How it started How it's going

Congrats to all involved in this fantastic study! It's super cool to see more ways in which promoter-proximal pausing is important in development.

One cross-country move and COVID-induced delay later, I'm excited to be starting my postdoc in the Glaunsinger lab at UC Berkeley where I'll study herpesviral late gene expression! Looking forward to getting involved in the Bay Area scientific community!

Happy to announce the final version of our paper is now available Nature Communications! nature.com/articles/s4146… Thank you to co-authors Kavya, Geoff Nelson Dr. Helena Zomer, Debarun, Irene, Reza, Huanyu, AdelmanLab and Prabu for a great collaboration of transcription and development expertise!

In this study, Rogers et al. use high-resolution genomic assays to comprehensively examine how Notch activates transcription of its target genes, showing that Notch releases paused RNA polymerase II from SWI/SNF-primed promoters. Learn more here: ➡️ tinyurl.com/gd352108