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Does a " synthetic embryo " made in the lab from stem cells have the potential to become an animal? It's a hot subject of debate. We visited a Florida barnyard where researchers are transferring blastoids to cows to see ... what develops.

Move over, Dolly the Sheep. Synthetic embryos could become "cloning 2.0". You might be able to generate thousands and thousands of identical embryos. That would be cool for animal breeding. "Like star wars for cows" one source told us.

From earning the #ISSCR Outstanding Young Investigator award to organizing our 2024 Earth Day webinar, Dr. Wu’s dedication to the stem cell community is inspiring! Read his Member Spotlight to learn how he became interested in his research👉 ow.ly/UN5N50Rmxxn Jun Wu Lab

How do chromatin modifications quantitatively impact gene expression? How do sequence variants or combinatorial marks influence relationships? We developed a modular #EpigenomeEditing toolkit to systematically test these Q, published today 🧵… nature.com/articles/s4158…

In this #50YearsofCell celebration focus issue on Developmental Biology, Jianping Fu and I authored a perspective summarizing the prospects and challenges of developing human organs using embryo models and interspecies chimeras. cell.com/cell/fulltext/…

Dr Klug discovered the C2H2 zinc finger and invented a way for their engineering as the basis for genome and epigenome editing (11433278). He should be by every objective criterion called a founding parent of both.

Have you ever wondered why some cell lines are easy to edit with CRISPR-mediated gene editing, while others are more difficult? Our paper is now online and offers an interesting answer: nature.com/articles/s4158…

Scientists are developing human embryo models, unlocking new insights into development, infertility, and birth defects. This cutting-edge research holds great potential, but also comes with challenges. Read more: nature.com/articles/d4158… Jun Wu Lab Dr Naomi Moris Marta Shahbazi Nienke de Graeff

C. David Allis and Michael Grunstein won the 2018 Basic #LaskerAward for discovering how histone modifications influence gene expression. ow.ly/8O4W50SKpsz Rockefeller University UCLA In just 5 days, we reveal the scientific breakthroughs recognized this year. #Lasker2024

Interested in piRNAs and transposon DNA methylation? Our new collaborative work revels a key mechanism underpinning the precision of piRNA-guided LINE1 methylation. Congratulation to all the authors! nature.com/articles/s4158…

Cool work by Aydan Bulut-Karslioglu & Nicolas Rivron showing diapuse like state can be induced in naive & intermediate naive-like (RseT), but not primed, human PSCs & in blastoids Cell mTOR activity paces human blastocyst stage developmental progression cell.com/cell/fulltext/…

The Dept of Molecular Biology at UTSW is recruiting new faculty! This is an amazing opportunity to join a vibrant research community with exceptional resources. Please apply using this link by Dec 7. jobs.sciencecareers.org/job/663016/ten…

Congrats Julia Phan + Aslan Tasdogan for their paper in Science today: hematopoietic stem cells (HSCs) & erythropoiesis get activated during pregnancy and after bleeding by retrotransposons that turn on in HSCs activating cGAS/STING & interferon signaling science.org/doi/10.1126/sc…

I am excited to share our review, published online today Nature Reviews Molecular Cell Biology. Pilong Li, Gaofeng Pei, Heankel Lyons, and I review the current literature on the regulation of transcription by condensates, large length-scale assemblies of complexes (Figure 1). nature.com/articles/s4158…

I’m thrilled to announce the launch of my lab at Westlake University Westlake University. We’ll focus on early embryonic development and stem cell-based embryo modeling. Postdoc positions are available.

Great article! by James Reddick ambrook.com/research/techn…

Incredible talk today by Kim Orth ! at Harvard Micro Harvard Medical School , incredible to see how a single Fido domain can evolve to make such a diversity of modifications. CRSM UT Southwestern Medical Center

Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts: Cell Stem Cell cell.com/cell-stem-cell…

The Gredler Lab Harvard University MCB_Harvard is hiring Postdoctoral Fellows! If you are interested in using high-resolution imaging of live embryos to ask how cells build tissues, please apply at the link below. #DevBio #sciencenews tinyurl.com/GredlerLab-Pos…