Excited to share a eukaryotic PIWI-related Asgard archaeal Argonaute that performs RNA-guided RNA Silencing! co-led by Daan C. Swarts Joo_Lab & me, spearheaded by Carolien Bastiaanssen Pilar B U Kijun Kim Yanlei Feng & giadafinocchio. biorxiv.org/content/10.110…

Our work with the fantastic Karol Buda is out in Nature Communications! We analyzed 41 fitness landscapes from adaptive Ez trajectories & report idiosyncrasy in 94% of mutational & epistatic effects! This high frequency may reflect the rewiring of intramolecular networks by evolution!

Are you interested in becoming a lab manager in a vibrant and exciting lab? Do you want to be surrounded by brilliant people? Read the information below and email us if you think you are fit.

New paper from the lab! We developed a super cheap protocol for bacterial RNAseq (~$25/txome) and screened drugs w/ gut microbes to generate 1000’s of txomes, the largest of its kind. Lots of cool insights and data for further follow up. Congrats to Deirdre, Yiming Huang

Just shared at Keystone Symposia a new @ArcInstitute discovery of the bridge RNA recombinase mechanism: a new class of natural RNA-guided systems that retains the key property of programmability from RNAi and CRISPR while enabling large-scale genome design beyond RNA and DNA cuts

Big congrats! This opens up a lot of new doors. We worked on a very similar approach with PRD1 and couldn't get it to work. Looking forward to reading this in detail. Now just fuse the GOI to the TP and display it covalently.

Do not use BioRender. Do not let abusive practices spread! There is an alternative! Use & Contribute to Simon Duerr 's open Bioicons! bioicons.com Illustrations are free to use and reuse, and they are available in SVG vector and PNG format without fees!

Introducing Genie 2, our latest protein design model! Genie 2 sets a new state of the art on key design metrics and supports motif scaffolding, including that of multiple motifs with undefined geometric relationships, a feature new to protein diffusion models. (1/5)

Do you really need to spread plasmid libraries on mountains of plates to get uniform growth, or can you just dump them in a flask and call it a day? We make huge plasmid libraries in the de Boer Lab, so we tested whether culture method really matters. 1/ biorxiv.org/content/10.110…

Meet MagLOV: an engineered protein that responds STRONGLY to magnetic fields. This is a fluorescence timelapse of MagLOV in E. coli. We're waving a (small) magnet under the plate. Can you tell where the magnet is? Want some? It's on Addgene now! addgene.org/219957/

Our preprint on engineered bacterial microlenses is out! We engineered bacteria to display sea sponge enzymes on their outer membranes. These bacteria can self-assemble a bioglass coating around themselves, and focus light into bright, photonic nanojets. biorxiv.org/content/10.110…

I'm partnering with Mike Knoop to launch ARC Prize: a $1,000,000 competition to create an AI that can adapt to novelty and solve simple reasoning problems. Let's get back on track towards AGI. Website: arcprize.org ARC Prize on Kaggle: kaggle.com/competitions/a…

🎉 Pilot Protein Engineering Tournament results are in! See benchmarking results for enzyme design models from in silico💻 to in vitro🧫 & the champion🏆Data, submissions, scripts & more!📊 Discover all the details here: alignbio.org/the-tournament… #ProteinEngineeringTournament2023

At proteinsociety tonight check out poster 73 with Andrew Holston to hear about our efforts to deorphanize sensor histidine kinases en masse & poster 117 with Natanya Villegas to hear about BAR-CAT, our approach to scalable enrichment of assembled gene libraries. Knight Campus

Interested in antibody generation and expression of human proteins in bacteria? If you're at proteinsociety tonight check out poster 75 at Bayshore Grand Ballroom D with Sayandeep to hear about expressing the human proteome in E. coli. Knight Campus

1/ 🧬 Excited to share CHEAP, our new work on compressed protein embeddings. We characterize the joint distribution of p(sequence, structure) in ESMFold's latent space, and find cool tidbits on compressibility, tokenizability, and pathologies: biorxiv.org/content/10.110… 🧵

Our Knight Campus iGEM Headquarters team this year is developing methods to fight enterohemorrhagic E. coli (EHEC). They just launched a University of Oregon DuckFunder fundraiser to send more team members to the final competition jamboree in France: duckfunder.uoregon.edu/project/42672

Interested in doing crazy/creative/high impact science at the intersection of ML/synthetic biology/gene regulation/genetics/personalized medicine? Due to a string of recent grant successes we have multiple postdoc openings... ubc.wd10.myworkdayjobs.com/en-US/ubcfacul… Thanks in advance for sharing!