It’s the year of the #PIC: Yeast Pol II pre-initiation complex at 2.9 Å resolution defines a unique mechanism of initial DNA opening. Tour-de-force by Sandra Schilbach with help from Shintaro Aibara & Christian Dienemann. Download the paper here: authors.elsevier.com/a/1dF84L7PXe~d…

ICYMI: Our understanding of human pol II transcription has been transformed over the past few months. Remarkable progress thanks to cryoEM PIC structures from Yanhui Xu lab @CramerLab Tjian + Darzacq Group @YuanHe_NWU. News/Views article here: go.nature.com/2SH3wEL

.Hauke Hillen and colleagues from Ricarda Richter-Dennerlein report cryo-EM structures with insights into the roles of several mitochondrial ribosome assembly factors. go.nature.com/3gznzya

Please RT! We're looking for a postdoc interested in investigating the structural basis of cellular function and disease in situ by #CryoET #teamtomo. Different projects and a suite of brand-new scopes are available 😀umg.eu/karriere/stell…

My first excursion to #cryoEM of fibrilar samples (grid prep optimization and data collection) led by the labs of Markus Zweckstetter and Gunnar Schröder Forschungszentrum Jülich | @[email protected]. Was quite a different experience compared to our daily SPA work.

Here is my almost 1-to-1 implementation of the #RELION gentle cleaning method in #Python. Added some extras like dry runs and absolute/relative paths. Useful for #cryoem data monitoring (messy users...) and cleaning before backup. github.com/cdienem/gentle…

#molnupiravir is a #COVID19 drug candidate that targets #SARSCoV2 polymerase and causes #coronavirus mutagenesis. In collaboration with Claudia Höbartner we provide the mechanism of this phase III #antiviral: nature.com/articles/s4159…

A study in NatureStructMolBiol reveals how the COVID-19 antiviral drug candidate molnupiravir causes lethal viral mutagenesis by the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2. go.nature.com/37wIbld

Molecular mechanisms of #corona drug candidate #Molnupiravir Free access link to paper: rdcu.be/ctQu2 Press release: mpg.de/17362204/0812-…

This is extremely valuable for everyone in #teamtomo!

Transcription-coupled DNA repair: After a long journey, we can now see how CSA, CSB, UVSSA and CRL4 remodel the transcribing Pol II complex for ubiquitination and DNA repair. Masterpiece by Goran Kokic. nature.com/articles/s4158…

Our work describing human transcription-DNA repair coupling in five ❄️EM structures is out nature. 🧬🥳 The centrepiece of coupling is the alternative transcription elongation complex that can ubiquitylate lesion-arrested Pol II and initiate DNA repair. nature.com/articles/s4158…

Encouraging results for the antiviral #molnupiravir: oral treatment of #covid19 patients reduces risk of hospitalization by ~50%. We had previously described its molecular mechanism: nature.com/articles/s4159… science.org/content/blog-p…

#cryoEMeme strongly instpired by @craigky 's brilliant talk at the recent Instruct-ERIC cryo-EM best practice meeting

Did you miss the Instruct-ERIC Best Practices in Cryo-EM Workshop? Fear not, you can watch the recording on the Instruct-ERIC YouTube channel 👇

#sunset #goettingen #mpibpc 🌅

We post shiny pictures, but this is real life EM!

I know what I need to get printed next...

Vote #teamcryo !❄️🔬

Just changed our SPA collection workflow in #SerialEM to "no script" and it is collecting 20% faster 🤩 Guenter Resch The new features in 4.0 rule!