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AC⚡️DC chromatin modules separated by TF activity

Define epigenetics:

Chromatin scientists, want to reorganize genomic loci as you wish? Out today in Cell--We made a tool that uses surface tension of engineered condensates to reposition DNA loci across microns of space in living cells in just a few minutes: VECTOR cell.com/cell/abstract/…

FINALLLY. (Warning, this is a long thread.) It has been a long battle. My current R01 was about to end in November this year. I might have needed to close my lab by next Spring. I truly believed in my projects, but without funding, I could not continue. >>>

Great suggestion, particularly for all first year students during this rotation season @unmcigpbs UNMC Dept of Genetics, Cell Biology & Anatomy UNMC Bioinformatics & Systems Biology

Wouldn’t it be great to test how individual transcription factors engage with their motif in the nucleus? We tried exactly that in a study lead by Ralph (Ralph Grand) and Marco (Marco Pregnolato) now out in Molecular Cell authors.elsevier.com/sd/article/S10…. 1/7

It is challenging to study the ability of transcription factors to engage their motifs in the cell. We tried to address this in our new study together with Marco (Marco Pregnolato), Schübeler Lab, and FMI science: cell.com/molecular-cell…

Awesome new paper just popped up in my feed. Congrats Kirkland_Lab! life-science-alliance.org/content/7/11/e…

Transcriptional control from stochastic action at the single-molecule scale

The first paper from our lab is now out in peer-reviewed form LifeScienceAlliance. Huge congratulations to the first author Mary Bergwell, Mary Bergwell, now in grad school at UPenn, and second author JinYoung Park! I am very proud of their hard work. They even let me do a few expts!

🎊🎉 #FragileNucleosome is back! You can now register for our 25th of September seminar session! We are excited to have ghost of RemiX Coux and Tom Vondriska talk about their research and kick-off #FragileNucleosome seminar series! 🗓️us06web.zoom.us/webinar/regist…

This looks pretty cool!

Excited to share the latest story from the @arnaud_kr lab EMBL ! Together with Christine Moene we used Single Molecule Footprinting to reveal that RNA Pol II occupancy occurs at surprisingly low-frequency at mammalian promoters! Thread below (⬇️) 1/11

Happy to contribute to this new preprint by Elena Pugacheva, Victor V. Lobanenkov 🇺🇦 & Co. What determines differential CTCF binding, beyond DNA methylation and TF/nucleosome competition? Answer: a specific nucleosome downstream of CTCF motif. Directionality matters! biorxiv.org/content/10.110…

With David and the Baker Lab in the spotlight today, I wanted to share some insights into the Institute for Protein Design and how it operates, a glimpse behind the curtain. I had planned to write this post-graduation, but now seems as good a time as any. (Got twitter blue free trial so this

Kudos to my outstanding team for developing genomic and epigenomic maps of mouse satellite regions (centromeres and pericentromeres), which account for ~11% of the mouse genome. Very excited to share the preprint. biorxiv.org/content/10.110…

Thrilled to share our new work bioRxiv: biorxiv.org/content/10.110… Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live cells. We reveal genome chromatin is essentially replicated from regions with greater nucleosome motions. 1/2

GCBA Seminar Series announces Aparna Bhaduri, PhD, Assistant Professor, University of California, Los Angeles (UCLA), Dept of Biological Chemistry presenting "Characterizing Cell Fate Specification in the Developing Human Brain and Glioblastoma" Aparna Bhaduri UNMC Dept of Genetics, Cell Biology & Anatomy UNMC Bioinformatics & Systems Biology

My guidelines for exploratory data analysis

My lab has been working for the past 15 years to develop a method to isolate specific genomic loci to identify its chromatin composition & protein interactome. Finally,… our superb physician/scientist Dr. Bercin Cenik Bercin K Cenik did it and here it is cell.com/molecular-cell… Not