Our #SingleCell dissection of #Schizophrenia genes/pathways, a new #TranscriptionalResilience cell type, target genes at #GWAS loci, and upstream #MasterRegulators is out @medRxivPreprint #PsychENCODE #BradRuzicka @Mohammadi_PhD #JoseDavila National Institute of Mental Health (NIMH) medrxiv.org/content/10.110…

Thanks Marija Marija Kundakovic !

This is a truly STUNNING piece of work. It’s packed with new and theoretically consequential information on biology of schizophrenia. Also a masterclass in scientific writing, analytic design and data viz. *emoji for standing ovation*

How do the hundreds of genetic risk-factors for #Schizophrenia actually lead to disease? New work medrxiv.org/content/10.110… from Manolis Kellis illuminates the #SingleCell landscape of #Brains from patients with #Schizophrenia and their healthy counterparts🔬🧠🧵1/10

Congratulations to Eric Lander who will become Presidential Science Advisor to Joe Biden! As Eric transitions to this new role, we welcome Broad’s Chief Scientific Officer Todd Golub as Director of the Broad Institute. Learn more: broad.io/LanderScienceA…

Excited to share our #SingleCell dissection of human #vasculature with #MyriamHeiman across 17 cell subtypes, human-specific #zonation, vasculature-coupled glia/neurons, and #Huntington's-associated #immune activation and #BBB integrity breakdown. #scBBB biorxiv.org/content/10.110…

Congratulations Myriam!

Excited to share our #SingleCell dissection of human #Hippocampus #EntorhinalCx #Anatomical substructures & stage-specific changes in #Alzheimers biorxiv.org/content/10.110… with @DrLiHueiTsai #JoseDavilaVelderrain Mathys Lab @Mohammadi_PhD @Brad_Ruzicka #DavidABennett #ROSMAP

Trying out spatial transcriptomics with 10x Genomics #Visium? Excited to share new package from our imaging analysis team that allow users to process, analyze, and interactively visualize the high-res images for integration with downstream gene expression analyses

Excited to share our #singlecell multi-cohort dissection of the transcriptome in #Schizophrenia medrxiv.org/content/10.110… with Brad Ruzicka Shahin Mohammadi @FullardJohn Manolis Kellis

Excited to share our #SingleCell dissection of #Schizophrenia, out in Science Magazine today, reporting 470k cells in 27 cell types across 140 individuals from 2 cohorts, revealing key insights on #ExcitatoryNeurons, #NeuroDevelopment, #Synapses, #1Cmetabolism, #Genetics,

Excited to share our #SingleCell #PSYCHENCODE24 study, reporting 470k cells in 27 cell types across 140 individuals from 2 #schizophrenia cohorts science.org/doi/10.1126/sc…

In the latest issues of Science, Science Translational Medicine, and Science Advances, the #PsychENCODE Consortium lay out findings based on examining human brains at the single-cell level. scim.ag/73Y (THREAD 🧵) #DecodingTheBrain