How low Magnesium may contribute to seizures Low magnesium → Subpar blockage of NMDA receptor → Excess activation of NMDA receptor → Massive calcium influx → Strengthening of synapse due to addition of AMPA receptors → Synapse responds stronger to future glutamate release

The Role of Inositol in Neurons Inositol is a sugar and popular supplement. It functions as a signaling molecule in neurons as part of phospholipase C (PLC) signal transduction. This is the signaling pathway for Gq linked GPCRs (i.e. 5HT2A). When a neurotransmitter binds to

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Bromantane experiment update after 2 months: - Cardio endurance is through the roof - Can squeeze out several more reps on compound lifts - Threshold to take action on menial tasks is lowered - 1 cup of coffee feels like 2 - Physical and mental fatigue accumulate slower

The two most obvious and well known pathways to leverage for cognitive enhancement are dopamine and acetylcholine But I still feel like the growth factor pathways are slept on Think Lion’s mane, Semax, and 4-DMA-7,8-DHF Not only do they produce a unique nootropic feel when you

The benefit of leveraging dopamine or acetylcholine over growth factors is it can be useful when you want to target specific behavioral outcomes Want to improve motivation/drive and focus? Go for dopamine Want more of an emphasis on focus and memory formation? Go for

The psychological outcome of any nootropic you take is going to be determined by its mechanism If you’re looking to improve memory and focus, go for something that boosts acetylcholine If you’re looking to increase motivation, drive, and focus, go for something that boosts