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We are excited to announce that researchers led by Ben Lehner have created the first comprehensive maps of allosteric sites on human proteins, also known as the "second secret of life". nature.com/articles/s4158…

Happy to share our new xQTLbiolink preprint, welcome for any comments and feedback!

This study is a bit of a thunder bolt. ~80% of genes DE b/n living & postmortem human brain medrxiv.org/content/10.110… No eQTL analysis. Surely that's to come. Incredibly important to see extent of (post mortem) effect modification... maybe a lot of GWAS loci to reinterpret 😕

The OPERA paper is published in Cell Genomics! The OPERA method integrates GWAS and xQTL summary statistics across multiple omics levels. Findings reveal that 50% of GWAS signals are shared with at least one xQTL signal. cell.com/cell-genomics/… Yang Wu Jian Zeng Westlake University

Excited to share our recent NAR paper that described an integrated human single-cell eQTL portal, which features 304 datasets across 57 cell types and 95 cell states. scQTLbase: an integrated human single-cell eQTL database academic.oup.com/nar/article/do… Nucleic Acids Res

Alternative polyadenylation is understudied in cells of the immune system. We constructed an atlas of APA events in various stimulation conditions, providing evidence of widespread stimulation-responsiveness and association with immune-related traits. nature.com/articles/s4146…

Excited to share that my first postdoctoral work is now online Nature Genetics: rdcu.be/dy7i9. We functionally dissect human cardiac enhancers and address how noncoding variants contribute to congenital heart disease. Thanks to all the people who contribute to this work.

Excited to share our new paper and describing a distinct class of alternative polyadenylation-mediated susceptibility genes for 22 major cancer types with 23,955 RNA-seq samples. We identified 642 novel APA-linked genes including CRLS1. nature.com/articles/s4146…

Excited to share a new paper describing a new regulator the E3 ligase RBBP6 as an essential factor for GSC maintenance. Wenyan Chen Lei Li nature.com/articles/s4142…

Excited to share the new paper by our lab in Science Advances . we developed a new computational method DATTSS and identified widespread dysregulation of tandem transcription initiation in human cancers, many of which are independent of gene expression. science.org/doi/10.1126/sc…