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Enfortumab vedotin & Pembrolizumab improving PFS & OS by 55% & 53% respectively compared to platinum based chemo in 1st line UC (+avelumab in 30%). Chemo has not been beaten before (despite multiple efforts). RR and CR of 68% & 29% is hard to beat. DOR not reached (1/3)#ESMO2023

Love seeing our Fox Chase Cancer Center crew at #ESMO2023 #ESMO23 ! Hossein Borghaei, DO Ben Miron Namrata (Neena) Vijayvergia MD

Congrats Ben Miron on presenting tumor fraction in ctDNA as a prognostic biomarker in mUC Ryon Graf, PhD Candice Nulsen Fox Chase Cancer Center Cleveland Clinic MD Elizabeth Plimack MD FoundationOne

Grateful for the unwavering support of my mentors Toni Choueiri, MD and Eli Van Allen It was a pleasure to present part of our work with Chris Labaki Ziad Bakouny, MD, MSc Ben Miron Matthew Zibelman Elizabeth Plimack MD Check out our poster # 459 at ASCO #GU24 on Saturday!

NECTIN4 amplification predicts response to Enfortumab vedotin in mUC! It occurs frequently across solid tumors (app. 25% of mUC)➡️potential tumor-agnostic biomarker for NECTIN4-targeting therapies! Happy to share our poster K17 ASCO #GU24! Markus Eckstein OncoAlert UroToday.com

❤️ Love our Fox Chase Cancer Center home team - couldn't ask for a better crew! Some not pictured, others covering back home, many Fox Chase Cancer Center Department of Urology contributions to #GU24

From NYSE: The co-founder of Scion Life Sciences on coming out of stealth mode and the new $310 million venture fund announced this week. Full video: biotechtv.com/post/scion-lif…

We report for the 1st time therole of tumor fraction in ctDNA in pts w/ mUC in RW Foundation Medicine 👉 ass. w/ clinico-path features & rwPFS 👉prognostic biomarker 👉may help personalize tx 👉prospective trials needed ESMO - Eur. Oncology Elsevier News Cleveland Clinic MD protect-us.mimecast.com/s/jGBqCR6nEvtn…

Excellent/elegant work by Ben Miron Shilpa Gupta et al. Agree that ctDNA holds high promise in UC. Its clinical utility regarding decision making needs well-designed trials with relevant endpoints Matt Galsky Hsieh Lab Joshua Meeks Parminder singh Gavin Ha Dr. Bishoy M. Faltas Uromigos

This trial will answer several important questions- do we need to escalate therapy to get better outcomes in the highest risk patients, and can we de-escalate in those who are lower risk. Matt Galsky Andrea Apolo, M.D. Tom Powles Guru P. Sonpavde, MD Tian Zhang, MD, MHS

It‘been a while, but 🎉🔬 The 17th episode is out. The last entity we tackled was the „incarnation“ of hot/inflamed urothelial carcinomas🔥🔥🔥🔥 But what do you know about PD-L1 testing ? Today Matt Galsky presented important data of CheckMate274 at #EAU24. PD-L1 positive

The #OncoAlertTOPtweet at Day 1 of #EAU24 Post By OncoAlert 🚨GU Faculty Tom Powles 🇬🇧 Serial ctDNA testing from IMVIGOR11 (post cystectomy in muscle invasive bladder cancer) show that ctDNA-ve patients (n=171) with a minimum of 12months follow up have 10% relapse rates and

So insightful! Never understood it as well until this explanation! Worth reading if you too have been stumped by the lack of consistency of clinical data when you group it together.

AR-PROTAC BMS-986365 is a potent & rapid AR degrader with enzalutamide-like antagonist potency, low AR agonism, weak activity against AR L702H, claimed to be selective against CRBN neosubstrates (data not shown) & allows to overcome AR feedback up-regulation. #AACR24 #TPD

Congratulations to the amazing Scott Kopetz for his AACR Waun Ki Hong Award. Eye opening listening to his presentation on Adaptive Resistance in BRAF- and KRAS-mutated #colorectalcancer #crcsm #AACR24 #AACRSSP MD Anderson Cancer Center

A lot about anti-NECTIN4 ADC Enfortumab vedotin (EV) beyond UC at #ASCO24! ASCO Data of multi-cohort EV-202 (NCT04225117) will be released! ➡️Excited to see the single-agent activity of EV in biomarker-unselected (NECTIN4 status not required!) - gastric/esophageal cancer

Hundreds of Jewish students at Columbia University just published one of the most incredible student letters I have ever read. It's not only magnificently written, but it also clearly articulates their experiences on campus for the past six months. Their letter tells the story of

TP53: - Discovered 45 years ago, most cited gene all time - No therapies - 500 million people currently living will die of TP53 mutant cancers without new therapies Our Preprint: - A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules

📢Close fup, limited censoring shows true OS durability in this small vanguard cohort of met #bladdercancer pts rx w EVP. Particularly impressive in cis inelig who often have comorbidities. Kudos to teams that invest in/prioritize long term follow up of metastatic trials! #ESMO24

💡Will #ctDNA serve as a treatment response biomarker in metastatic cancers? Here’s a thorough evaluation in Clinical Cancer Research from the RECIST working group, looking at the next steps towards using ctDNA for novel early endpoints in clinical trials and beyond. 👉 doi.org/10.1158/1078-0…