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Excited to share new work that truly spanned bench (computer) to bedside a thread 🧵(1/n) alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Folks- I have a preprint update on our #dopamine quest: "Cholinergic Interneurons Drive Motivation by Promoting Dopamine Release in the Nucleus Accumbens". I will try to summarize it here: biorxiv.org/content/10.110… 1/9

This is a great collection of reviews on the immune system in PD, including from Cecilia Lindestam Arlehamn Alessandro Sette and many others! David Sulzer and I wrote about neuronal antigen presentation: content.iospress.com/articles/journ…

If you thought ATAC was cool, wait til you see DEFND-seq!🛡️🧬🔥 Single-nucleus combined RNA/DNA-seq using the 10x Multiome kit! Amazing work from Tim Olsen

How can we kill chemo-resistant glioma cells? Turns out they are uniquely vulnerable to #ferroptosis. Awesome collaboration with Columbia Translational Brain Tumor Laboratory Matei Banu combining a new mouse glioma model with human glioma slice culture/scRNA-seq: biorxiv.org/content/10.110…

If you wish to know how a scientist gets trapped between arts and science you might want to give this piece a chance!😂🐘🐘🐘🧠🧠🧠🎶🎹🪕🎻 David Sulzer’s Wild World of Music | The New Yorker newyorker.com/magazine/2023/…

Thrilled to see this #glycotime story finally out! Congrats Mazdak Bradberry on uncovering this fantastic resource. N-glycoproteomics of brain synapses and synaptic vesicles | Cell Reports sciencedirect.com/science/articl…

Proximity labeling is a powerful proteomics approach to map cellular organization of proteins and their interactions, but the multistep sample preparation has restricted scalability. Our new preprint offers a solution: biorxiv.org/content/10.110…

We’re THRILLED to have this paper out - exploring how BAMs promote neuroinflammation in a model of PD. Congrats to Dr. Aubrey Schonhoff and huge thanks to Aligning Science Across Parkinson’s michaeljfox.org UAB Medicine UAB Department of Neurology and the rest of the Harms lab!! nature.com/articles/s4146…

Nat Biotech recently published a provocative study claiming single synapse RNA-seq. Unfortunately, there is no evidence demonstrating droplet-based sequencing of single synaptosomes. They are likely studying random pieces of cellular debris. Our reply: nature.com/articles/s4158…

Massive 10+ year effort in lab spearheaded by Leonardo Parra-Rivas and Kayal (secret account 🤔). Unreal cover by Emma VIDAL that says it all.

So excited to see our work on "Profiling the proximal proteome of the activated μ-opioid receptor" using APEX-based proximity labeling and quantitative mass spec published today. It is the result of an amazing team effort! nature.com/articles/s4158… #TeamMassSpec #Proteomics #GPCR

Beautiful work… This study is so exciting! Among many exciting findings, the authors found ultrastructural evidence for localization of TRiC/CCT in DA axons and the lack of axonal ribosomes in DA neurons, corroborating in vivo results from my graduate studies

Thrilled to see our paper "A Proximity Proteomics Pipeline with Improved Reproducibility and Throughput" published! It describes the automated enrichment of biotinylated proteins in a 96-well plate format for spatial proteomics and protein interactions. embopress.org/doi/full/10.10…

And we are LIVE! @sthom003 and I finally have our lab website. Check out the Laboratory of Translational Psychiatry and all the great work by our team. 🧠Research, Training and Community. Thanks to Stellate Communications for their ingenuity on this. balethompsonltp.org

Electrical synapse molecular diversity revealed by proximity-based proteomic discovery biorxiv.org/cgi/content/sh… #biorxiv_neursci

Hello world! After my lab has been operating in "stealth mode" for 1.5 years, I am excited to announce that we finally have a website: huttenhainlab.com By the way I'm also hiring and looking for a postdoc with proteomics experience: postdocs.stanford.edu/prospective/op… #TeamMassSpec

200 retweets and I’ll do the 200/400 double at worlds…. I’ll beat Noah and Vernon 😂🤝🏾… Grant also gotta see me in the 110 too.. I’ll take the stripes off his lil vest

📣 New today! 📄Genome-wide prediction of dominant and recessive neurodevelopmental disorder-associated genes 🧑‍🤝‍🧑Ryan Dhindsa Anthony Zoghbi & colleagues cell.com/ajhg/abstract/…