Our latest paper for the discovery of a new dialkyl pyrone derived from a fungal PKS-NRPS enzyme with a non-functional NRPS module has just been published. Congratulations Seki-san for the first paper in Japan! sciencedirect.com/science/articl…

Happy to announce that our latest paper uncovers a unique pair of terpene cyclases, AsPS and AsCPS, in the fungus Arthrinium sacchari, leading to the biosynthesis of (–)-sandaracopimaradiene. Congratulations Fumito on his first paper! beilstein-journals.org/bjoc/articles/…

A01成果発表：クモ内生糸状菌から二種のテルペン合成酵素が協働するラブダン型ジテルペン生合成経路を発見。 doi.org/10.3762/bjoc.2…

We’re excited to celebrate the 5th anniversary of our lab, which was established in October 2019🎉 A big thank you to all our collaborators and lab members for their dedication and contributions!!

Excited to share our latest paper has just been published in Organic Letters! We successfully achieved the on-DNA synthesis of polyketide-peptide hybrid macrocycle toward the construction of DEL. Congratulations to Soya on his first paper! pubs.acs.org/doi/10.1021/ac…

当研究室の惟村さんの研究成果がプレスリリースされました。 tohoku.ac.jp/japanese/2024/…

Happy to share our latest paper in J Org Chem/Org Lett! We uncovered the biosynthetic pathway of circumdatins, featuring a unique anthranilate-tailoring route for NRPS substrate supplies. Congrats to Yura on his first paper! pubs.acs.org/doi/10.1021/ac…

Thrilled to share our latest paper just out in J. Am. Chem. Soc.! We uncovered an unprecedented KS domain-catalyzed β-lactonization in the biosynthesis of the HMG-CoA synthase inhibitor hymeglusin. Huge congratulations to Mizuki on his first paper! 🎉 pubs.acs.org/doi/10.1021/ja…

Ketosynthase Domain Catalyzes β-Lactonization in the #Biosynthesis of the HMG-CoA Synthase Inhibitor Hymeglusin by Mizuki Hirokawa, Taro Ozaki, Kento Tsukada, Akihiro Sugawara, Yohei Morishita, and Teigo Asai in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

🟡#研究成果 #プレスリリース β-ラクトンの新たな生合成機構を解明 新たな創薬リードの探索に期待 #東北大学 #大学 #SDGs 📗本件論文はコチラから doi.org/10.1021/jacs.5… 🔻本件ポイントはこちら🔻 tohoku.ac.jp/japanese/2025/…

【注目プレスリリース】β-ラクトンの新たな生合成機構を解明 新たな創薬リードの探索に期待 / 東北大学 research-er.jp/articles/view/…

第25回 天然薬物の開発と応用シンポジウム 10月11日（土）〜12日（日）に東北大学にて開催されます。 現在、発表演題を募集中です。 発表申込締切：7月25日（金） 皆様の積極的なご応募をお待ちしております！ tennen2025.wixsite.com/sendai/%E5%8F%…

The Ozaki (A01) group, in collaboration with Prof. Teigo Asai group Asai_lab., demonstrated that the ketosynthase domain of a highly-reducing polyketide synthase catalyzed β-lactone formation in the biosynthesis of hymeglusin. J. Am. Chem. Soc. pubs.acs.org/doi/full/10.10…

第25回 天然薬物の開発と応用シンポジウム 発表申込締切を2025年8月1日まで延長しました。 皆様の積極的なご応募をお待ちしております！ tennen2025.wixsite.com/sendai

Our new paper is out J Org Chem/Org Lett (open access)! Through genome mining of a fungal endophyte, we discovered new natural products with unique pyrano[2,3‑c]pyrrole scaffolds. Congrats to Seki-san on this 2nd paper from the pdD project! pubs.acs.org/doi/10.1021/ac…