The strain right now seems more than the society can cope with. We need leadership now more than ever at every level to redirect misplaced anger, to bring reform and to heal.

The complexity of cell death- is there such a thing as a terminal effector? Or is each step heavily regulated and intricately linked to other cellular processes?

Great blog post from Alina and Beth on the microbiome and colorectal cancer ndorms.ox.ac.uk/news/blog/can-… following their recent review nature.com/articles/s4158…

This!

Can’t believe the day has come and it’s here!😭 If I were the sensational type I might say that we discovered that stressed out parents make sexy kids, grandchildren and grand-grandchildren. But I’m going to do the responsible thing & explain it carefully in the thread below🍾👇

Excited to share our new work identifying an inflammatory lectin alarmin/DAMP released during lytic cell death (pyroptosis & necroptosis). Congrats to Ashley Russo, who led the work. Big thanks to our collaborators across the globe for making it possible!! nature.com/articles/s4159…

A new year and a new Inflammazoom. The next exciting instalment will be from Eicke Latz and @russellevance. You may be feeling a bit of a zoombie, but don't miss these exciting talks!

New pre-print describing heterogeneity in IBD to inform therapeutic strategies. Great work! @MathildePohin @matta_jackson Ilya Korsunsky

Encountered yet another case of a US-based PI holding a threat of not renewing immigration status as a power move over international postdocs. You would think that the pandemic would make folks behave better but in fact it’s the opposite. Please... don’t be this PI; be better

@evolscientist Ran Blekhman Harmit S. Malik The real solution is most likely at the policy level. Universities and funding agencies have the power to implement strategies to track abusive PIs, protect people who work with them, and prevent them from being able to hire more without supervision.

Please RT! Looking for a PhD student to bridge laboratory & field for vaccine/immunotherapy development for Tasmanian devil transmissible cancers. Veterinarians encouraged to apply. Andy Flies tinyurl.com/bbfwd79c. University of Tasmania Menzies Institute for Medical Research WACImmuno

Aberrant localization of CDC42 C-terminal variants to the Golgi apparatus drives pyrin inflammasome-dependent autoinflammation biorxiv.org/cgi/content/sh… #biorxiv_immuno

Innate riddle of CD4+ T cells and the control of enteric infections dlvr.it/SV0JCB

Nature research paper: Epithelial IFNγ signalling and compartmentalized antigen presentation orchestrate gut immunity go.nature.com/40RB6ql

Online Now: Melanoma and microbiota: Current understanding and future directions dlvr.it/T0kybh

Sensing of interferon-γ triggers antigen presentation by colonic epithelial cells, enabling T cells to lower extracellular ATP levels and reduce inflammation nature.com/articles/s4159… Nature Immunology Comment on nature.com/articles/s4158… Bana Jabri Ankit Malik

Out now! Gut bacteria encode an unprecedented number of enzymes for anaerobic respiration of biomedically relevant substrates by Sam Light Ashley Sidebottom Michael Mullowney A. Murat Eren (Meren) Matthew S. Schechter Kaylie Scorza Deepti Sharan Emily Waligurski Matt Odenwald nature.com/articles/s4156…

💡 UChicagoCancerCenter researchers unveiled the secrets of epithelial cells to battle IBD and prevent colorectal cancer! 🔬🔍🧬🦠 UChicago Biological Sciences Bana Jabri #AnkitMalik Nature Portfolio UChicago Digestive Diseases #BreakthroughScience #HealthInnovation ow.ly/orIs50QwSOT

I'm deeply honored and grateful to receive the 2024 Young Investigator Award by the Cancer Research Foundation. This funding will boost our research on ion channels in the context of tumor immunotherapy.