So great to see our GWAS of ADHD out in Nature Genetics👏👏👏👏

Recent GWAS of school grades finds genetic overlap between language ability🗣, psychopathology🧠 and creativity🎨. Also using #ADHD summ stats from PGC Consortium Work lead by Veera Rajagopal , Ditte Demontis, Anders Børglum, and many more!! nature.com/articles/s4159…

A genome-wide meta-analysis of data from 6 US and European cohorts involving 1.3 million individuals identifies 243 genetic variants associated with risk and pathophysiology of depression Anders Børglum nature.com/articles/s4159…

PGC Consortium are dismayed that Orchid’s embryo testing includes common chronic disorders such as schizophrenia orchidhealth.com/science Their information on the genetics of schizophrenia refers to PGC Consortium research guides.orchidhealth.com/post/is-there-…

The PGC Consortium hosts genetic summary results for use by researchers. Any use for commercial testing or for testing of unborn individuals violates the terms by which PGC & our collaborators’ data are made available

Data are provided on the following conditions only (both of which must be met): 1. Investigators will only use these data for non-commercial scientific research 2. Investigators may not use these data to develop any predictive tests for an unborn individual

Any commercial or for-profit use of these data requires permission in advance from the PGC Data Access Committee

The ISPG have written on the topic of embryo screening here, for those who are interested in the ethics of testing unborn individuals sciencedirect.com/science/articl…

Whole, healthy human brain data is now on the ABC Atlas! Dataset incl. 3 million+ cells sampled from dissections from adult donors. Samples underwent snRNA sequencing and were clustered and categorized by neurotransmitter, region, and more. ABC Atlas: portal.brain-map.org/atlases-and-da…

In this preprint, Aylwyn Scally, Richard Durbin and I present evidence for deep population structure shared by all modern humans biorxiv.org/content/10.110… Aylwyn Scally Richard Durbin

Our latest paper in JAMA Psychiatry led by the academic star Sophie Legge Genetic and Phenotypic Features of Schizophrenia in the UK Biobank jamanetwork.com/journals/jamap…

When a long-term memory forms, some brain cells experience a rush of electrical activity so strong that it snaps their DNA. Then, an inflammatory response kicks in, repairing this damage and helping to cement the memory, a study in mice shows go.nature.com/43DZQns

What predicts mental illness? The largest meta-analysis of antecedents to depression, bipolar disorder and psychosis to date is here: authors.elsevier.com/a/1iqXVY3M3i1ki

“The brain’s complexity and diversity surprised us,” recalled Hongkui Zeng Allen Institute. She and a network of researchers charted a colorful cellular map of the mouse brain, shedding light onto thousands of cell types and their intricate connections. bit.ly/3POO3wJ

Current goals of the PGC-ADHD working group are to: 📈Increase number of ADHD cases with genome-wide genotype data to 100,000 🌍Expand diversity of ancestral populations in our analyses 🧬Extend our work into exome/genome sequencing and copy number variants (CNVs)

🚺🚹Ever wondered why females are less likely to be diagnosed with #ADHD in childhood than males? Check out this recent review by Dr Joanna Martin. pubmed.ncbi.nlm.nih.gov/38340761/ She discussed the role of biological, sociocultural and diagnostic practices and services

Super proud of this collaboration with Camiel Mannens Sten Linnarsson who created a map of chromatin accessibility during early embryonic development. Exciting resource for genetics people! Thanks to Marijn Schipper from #ctglab for being part of this. See: nature.com/articles/s4158…

Massive thank you to more than 5 million participants & 300 investigators worldwide who made this study possible

So excited that our paper “De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome” is out today in nature nature.com/articles/s4158… 🧵 1/16