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Can't escape T cell exhaustion in the latest Nature Immunology, with a triptych of papers from: Debattama Sen E. John Wherry, Georg Lauer and a great N&V explainer from Hazem Ghoneim nature.com/ni/volumes/22/… [1/n]

The Ghoneim Lab’s research is redefining immunotherapy by improving the clinical interventions used to tackle & prevent the recurrence of chronic infections & cancer. Learn more about their work in this latest #OSUCOM blog #cancer The James go.osu.edu/CA5Y

There is no need to worry about exhaustion from a 4 vaccine dose. This is not how exhaustion works. Chronic infection with SARS-CoV-2 - that could give you exhaustion and is much (MUCH) more likely if you are unvaccinated.

Congrats to The Ohio State University Wexner Medical Center The James researcher Hazem Ghoneim & his lab on their 1st paper published in Nature Immunology. “Rebalancing TGFβ1/BMP signals in exhausted #Tcells unlocks responsiveness to #ImmuneCheckpoint blockade.” Nat Immunol 2022. rdcu.be/c12J0

SPOTLIGHT: Pelotonia Pelotonia Institute for Immuno-Oncology Hazem Ghoneim Amir Yousif demonstrated that chronic TGFβ1 signaling epigenetically remodeled CD8+ T cells to accelerate and stabilize a terminally dysfunctional CD8+ T cell state upon persistent TCR stimulation 👉 ow.ly/2imQ50MnM64

.Abbey discusses how rebalancing TGFβ1 and BMP signals in exhausted T cells restores response to immune checkpoint blockade. Nature Immunology Hazem Ghoneim The Ohio State University Wexner Medical Center The James #JRNLclub jrnlclub.org/research-films…

Kudos to #PIIO Founding Director, Dr. Zihai Li, MD, PhD Li (Ohio State Medical Oncology) and #PIIO #MIIStrong Member Dr. Hazem Ghoneim! They will chair an #AAI2023 Block Symposium titled "#TCells in #Cancer: From Memory to Exhaustion" on 5/12 @ 3:45PM in Room 204ABC. Not to be missed‼️‼️‼️

Awesome job by PhD candidate Amir Yousif, who represented #MIIProud, #PIIO Hazem Ghoneim Lab at #AAI2023 with poster titled "Targeting #epigenetic crosstalk that restrains the responses of #ExhaustedTcells to #ImmuneCheckpointBlockade therapy"!!

Congrats to The Ohio State University Wexner Medical Center, The James, #MIIProud, #PIIO researcher Dr. Hazem Ghoneim, who was awarded an NIAID R01 titled: "Enhancing the Effectiveness of #Immunotherapies by #TCell #Epigenetic Reprogramming." (1/2)