White, Grillo-Hill and colleagues reveal β-catenin is a pH sensor with decreased stability at high pHi. They identify a molecular mechanism: high cellular pH increases β-catenin association with the E3 ligase β-TrCP. UC San Francisco @kwhitelab San José State University Grillo-Hill Lab bit.ly/2PCNqFm

Had a great pre-#ASHG18 cancer variant #hackathon and curation jamboree with CIViCdb team, ClinGen, Disease Ontology The NDEx Project MyGene.info IGV Team @CravatMupitTool and more, Andrew Su hosting and support from National Cancer Institute #nciitcr and ISB Int Soc Biocuration.

Mathematical modeling reveals spontaneous emergence of self-replication in chemical reaction systems jbc.org/content/early/…

Dr. Danos describes integration of biological information into CIViC evidence items Arpad Danos #ashg18

Economic inequality is higher in the U.S. than virtually all other advanced countries. What can we do about it? Nobel Prize-winning economist Joseph E. Stiglitz explains the origins of this imbalance and suggests measures to alleviate it. bit.ly/2QZKjrv

Dr. Alex Wagner discusses #VICC at #ashg18 with Jax labs #civicdb Alex H. Wagner

Blog: Could the IPCC’s scary new report finally stir us to take immediate action on climate change? If not, the cost will be staggering. bit.ly/2CUwoQw

As we go through life, our cells pick up a lot of mutations, but they don't necessarily have the effects we'd expect. Read the research: ($) scim.ag/2NNqhP6

Regulation, data collection and cost all hamper efforts to find better ways to prescribe antibiotics. go.nature.com/2AjDIm8

Phospholipase D–dependent mTOR complex 1 (mTORC1) activation by glutamine: jbc.org/content/early/…