🧬 Thrilled to share our latest research on Retrons—a new chapter in this fascinating field! 🌟In this Molecular Cell paper, we reveal how Retron-Eco1 defends against phages. bit.ly/3WOlbsY Check the 🧵below! (1/20)

Multitrons: simultaneous multi-site editing of individual genomes using retron arrays, now published in Nature Chemical Biology Nature Chemical Biology: nature.com/articles/s4158…. Great job Alex González-Delgado and oso !

An explainer/behind-the-scenes: gladstone.org/news/new-one-s… via Gladstone Institutes.

🚨 NEW PUBLICATION🚨 "Simultaneous multi-site editing of individual genomes using retron arrays" go.nature.com/3xGlOe7 Seth Shipman Nature Chemical Biology UC San Francisco Chan Zuckerberg Biohub Network oso Alex González-Delgado Matías Rojas Montero chloe UCSF Bioengineering & Therapeutic Sciences

So excited to share one of the final works from my PhD in Seth Shipman’s lab with Asim Khan and oso, where we used high-throughput libraries and machine learning to create design rules for retron gene editors: biorxiv.org/content/10.110…

New Preprint of kate crawford's graduate work! Kate's thread below hits all the highlights. Thanks for the ML on this one Hani Goodarzi. UC San Francisco Gladstone Institutes BioE_BEAST UCSF Bioengineering & Therapeutic Sciences

Continuous multiplexed phage genome editing using recombitrons go.nature.com/3yUNYTi

Multiplexed editing of phage genomes using retrons, now published at Nature Biotechnology with lots of new bells and whistles. chloe kate crawford Santi Bhattarai-Kline Darshini Poola Karen Zhang Alex González-Delgado Matías Rojas Montero nature.com/articles/s4158…

A team at Gladstone developed a technology that lets them edit the genomes of bacteria-fighting viruses, known as phages, in a streamlined and highly effective way. Seth Shipman kate crawford chloe Nature Biotechnology UC San Francisco UCSF Bioengineering & Therapeutic Sciences Chan Zuckerberg Biohub Network bit.ly/3XIW4rL

The link for the faculty position is now posted! Deadline is October 15th. Please share widely with talented scientists in your network. Come join us at UCSF! aprecruit.ucsf.edu/JPF05243

An experimental census of retrons, now published in Nature Biotechnology. We synthesized more than a hundred new retrons and put them through their paces, improved recombineering rates and precise editing in human cells up to 40%. nature.com/articles/s4158…

An experimental census of retrons for DNA production and genome editing go.nature.com/3MOsMBx

Gladstone scientists undertake a major effort to examine the diversity of retrons, bacterial defense systems that can be leveraged for precise gene editing. Seth Shipman Asim Khan Matías Rojas Montero Alex González-Delgado Nature Biotechnology UC San Francisco UCSF Bioengineering & Therapeutic Sciences Chan Zuckerberg Biohub Network bit.ly/3XIMoxb

The role of noncoding RNAs in bacterial immunity Review by Rafael Pinilla-Redondo and colleagues Mario R Mestre Huijuan li Rafa Pinilla-Redondo dlvr.it/TFL77G

Excited to share our last collab paper in Nature Communications on the structure & interference mechanism of the mysterious 𝗧𝘆𝗽𝗲 𝗜𝗩-𝗔 𝗖𝗥𝗜𝗦𝗣𝗥-𝗖𝗮𝘀 system!! 🧬🚀 🔗nature.com/articles/s4146… 🧵 by @patrick_pausch below!

🧬🧬 𝙉𝙚𝙬 𝙋𝙧𝙚𝙥𝙧𝙞𝙣𝙩!!🧬🧬 Latest collab with the amazing Ming Li & Yue Feng labs! How do phages bypass multi-layered defenses in bacteria? Spoiler: with equally complex anti-defenses!! 🧵👇 biorxiv.org/content/10.110…

C. acnes is the most abundant bacterium on human skin. But what if we could make it the smarterst? 🦠✨ In our new Cell-Systems study, we programmed C. acnes to actively protect the skin for therapeutic applications! 🛡️ authors.elsevier.com/sd/article/S24…

The June issue is live nature.com/nbt/volumes/43… On the cover, Khan et al. present a molecular census of retrons, performing the same battery of tests across many distinct systems to identify similarities and differences go.nature.com/3MOsMBx

New Preprint!! Alex González-Delgado accomplished a major feat on this one: ported retron recombineering, which we love so much in E. coli, into 14 new bacterial species via a massive collaborative effort involving 9 labs! biorxiv.org/content/10.110…