So happy and proud to see this in print. Almost 4yrs from conception to publication, but worth the wait! Checkout Tweetorial below!! Coupling of protein condensates to ordered lipid domains determines functional membrane organization science.org/doi/10.1126/sc…

New preprint! Minghao Chen determines the structures of the ULK1 complex core and PI3KC3-C1. We find that these two complexes come together to form a much larger autophagy initiating super complex, with implications for the activation mechanism of ULK1. tinyurl.com/3nsshhme

Thanks to TCHResearchNews for the news release!

Thank you @NIHDirector for sharing our discovery!

BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

It was a pleasure to present at the #NCL2023! Lots of interesting talks and posters!

#jobopportunities Cristina Sorrentino is looking for a Research Fellow and a Post Doc who will be involved in a project focused on the development of new drug therapy protocols for the treatment of CNS and retinal pathology in a mouse model. More: tigem.it/newsroom/caree…

Want to know more about how the presynaptic compartment is formed and assembled in human neurons? Please see Sila's new paper form our lab just out in Science: DOI: 10.1126/science.adg1075.

Attention cell biologists and lipid lovers: Want to visualise phosphoinositides without hassle and adverse effects of overexpression? · Multiplex stain for all 8 PIPs · Super-resolution imaging of nanoscale organisation · From 2D to whole tissue (1/9)👇 biorxiv.org/content/10.110…

How can lysosomes, when ruptured, maintain stability allowing for repair? Glad to share nature nature.com/articles/s4158… the function of stress granules (SG) as molecular plugs that stabilise damaged membranes The Francis Crick Institute Max Gutierrez #condensates #lysosomes #TB👇Thread

Today we celebrate the #WomenInScience International Day! Read a special interview to our Postdocs Simona Brillante & Francesca Carriero here: tigem.it/newsroom/news-…

Excited to share our paper by Raffaella De Pace Saikat Ghosh et al. showing that BORC-dependent transport of lysosomal vesicles into the axon is crucial for the axonal movement of a large cohort of mRNAs, mainly those encoding ribosomal and mitochondrial proteins nature.com/articles/s4159…

We like projects that involve #organelle crosstalk and take us to unexpected places. This one started on #lysosomes and ended up at the #nucleus. Congratulations to Neuza Domingues for going "all in" and a grateful thank you to all our collaborators. biorxiv.org/content/10.110…

Thrilled to share our latest publication: "Raghopathies and the Rising Influence of RagGTPases in Human Diseases.” 📖 Read more here: rdcu.be/dNmLC happy to see how this research can help future studies and potential treatments! Tigem Telethon Nature Communications

Excited to participate in the celebration of Tigem Telethon 30th anniversary and Andrea Ballabio’s retirement as founding director. So many AWESOME achievements by TIGEM and Andrea! 🎉🔬 #lysosome #TFEB

Congratulations, Benham-Pyle Lab, @BoeynaemsSteven and Hongjie Li, recipients of a 2024 NIH Director's New #Innovator Award! BCMHouston Dan L Duncan Comprehensive Cancer Center BCM Department of Molecular and Human Genetics TCHResearchNews CPRIT commonfund.nih.gov/newinnovator/A…

Excited to share ‘Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins’, by phenomenal superstar postdoc Aakriti Jain Aakriti Jain and amazing collaborators Rushika M. Perera, Guido Bommer, Charly Craik and James Olzmann: science.org/doi/10.1126/sc…

Happy to announce the first speaker of our new webinar series of the ESGLD: Andrea Ballabio. This series of webinars will feature prominent scientists in lysosome research, so if you are interested in lysosomes and their roles in human disease, don't miss it!